Comparative heating efficiency and cytotoxicity of magnetic silica nanoparticles for magnetic hyperthermia treatment on human breast cancer cells

Magnetic hyperthermia (MHT) is a promising treatment for a variety of cancers due to its ability to increase the sensitivity of cells to other treatments, such as chemotherapy. Superparamagnetic nanoparticles (MNPs) were used for MHT treatment due to their heat generation ability under an AC magneti...

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Bibliographic Details
Published in:3 Biotech 2022-11, Vol.12 (11), p.313-313, Article 313
Main Authors: Acar, Melek, Solak, Kubra, Yildiz, Seyda, Unver, Yagmur, Mavi, Ahmet
Format: Article
Language:English
Subjects:
Agriculture
Bioinformatics
Biomaterials
Biotechnology
Breast cancer
Cancer Research
Cell death
Chemistry
Chemistry and Materials Science
Chemotherapy
Cytotoxicity
Heat generation
Heating
Hyperthermia
Iron oxides
Magnetic cores
Nanoparticles
Original
Original Article
Silica
Silicon dioxide
Stem Cells
Toxicity
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Summary:Magnetic hyperthermia (MHT) is a promising treatment for a variety of cancers due to its ability to increase the sensitivity of cells to other treatments, such as chemotherapy. Superparamagnetic nanoparticles (MNPs) were used for MHT treatment due to their heat generation ability under an AC magnetic field (AMF). In this study, iron oxide and zinc-doped iron oxide MNPs were produced and modified with silica to obtain eleven different types (MSNP-I to -XI) of magnetic silica nanoparticles (MSNPs). The MSNPs which show the highest heating capacity were selected to investigate their MHT ability on non-tumourigenic MCF-10A and tumourigenic MCF-7 cell lines. The cytotoxicity results indicated that the size, the content of the magnetic core and silica coating thickness were important in the heating capacity of MSNPs under AMF. After MHT treatment, selected MSNPs showed limited cytotoxicity on MCF-10A, but significant cell death on MCF-7.
ISSN:2190-572X
2190-5738
DOI:10.1007/s13205-022-03377-y