Clinicopathological Significance of STAT3 and p-STAT3 among 91 Patients with Adenocarcinoma of the Esophagogastric Junction

Adenocarcinoma of the esophagogastric junction (AEG) has increased rapidly worldwide during the last few decades. The purpose of this study is to investigate the clinical and prognostic characteristics of signal transduction and activator of transcription factor 3(STAT3) and phosphorylated STAT3 (p-...

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Bibliographic Details
Published in:Disease markers 2022-10, Vol.2022, p.1-12
Main Authors: Ma, Rui-Jie, Zheng, Qi-Ming, Zhang, Nan, Sun, Zhi-Gang
Format: Article
Language:English
Subjects:
Adenocarcinoma
Cancer therapies
Chemotherapy
Differentiation
Esophagus
Gastric cancer
Gender
Kinases
Lymph nodes
Lymphatic system
Medical prognosis
Metastases
Metastasis
Patients
Proteins
Radiation therapy
Regression analysis
Risk analysis
Risk factors
Signal transduction
Stat3 protein
Survival
Thoracic surgery
Transcription factors
Tumors
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Summary:Adenocarcinoma of the esophagogastric junction (AEG) has increased rapidly worldwide during the last few decades. The purpose of this study is to investigate the clinical and prognostic characteristics of signal transduction and activator of transcription factor 3(STAT3) and phosphorylated STAT3 (p-STAT3) expression in AEG patients. We retrospectively analyzed the immunohistochemical results of 61 AEG patients and followed up for 5 years, while Western blot was performed on tissues from another 30 AEG patients. The results showed that STAT3 and p-STAT3 were overexpressed in AEG tissues (P
ISSN:0278-0240
1875-8630
DOI:10.1155/2022/9311684