Signaling through Free Fatty Acid Receptor 4 Attenuates Cardiometabolic Disease

A surge in the prevalence of obesity and metabolic syndrome, which promote systemic inflammation, underlies an increase in cardiometabolic disease. Free fatty acid receptor 4 is a nutrient sensor for long-chain fatty acids, like ω3-polyunsaturated fatty acids (ω3-PUFAs), that attenuates metabolic di...

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Bibliographic Details
Published in:Physiology (Bethesda, Md.) Md.), 2022-11, Vol.37 (6), p.311-322
Main Authors: O'Connell, Timothy D, Murphy, Katherine A, Zhang, Naixin, Puccini, Sara J, Healy, Chastity L, Harsch, Brian A, Zhang, Michael J, Shearer, Gregory C
Format: Article
Language:English
Subjects:
Cardiovascular Diseases
Fatty Acids, Nonesterified
Fatty Acids, Omega-3 - metabolism
Fatty Acids, Omega-3 - therapeutic use
Humans
Inflammation
Review
Signal Transduction
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Summary:A surge in the prevalence of obesity and metabolic syndrome, which promote systemic inflammation, underlies an increase in cardiometabolic disease. Free fatty acid receptor 4 is a nutrient sensor for long-chain fatty acids, like ω3-polyunsaturated fatty acids (ω3-PUFAs), that attenuates metabolic disease and resolves inflammation. Clinical trials indicate ω3-PUFAs are cardioprotective, and this review discusses the mechanistic links between ω3-PUFAs, free fatty acid receptor 4, and attenuation of cardiometabolic disease.
ISSN:1548-9213
1548-9221
DOI:10.1152/physiol.00007.2022