One-tissue compartment model for myocardial perfusion quantification with N-13 ammonia PET provides matching results: A cross-comparison between Carimas, FlowQuant, and PMOD

To cross-compare three software packages (SPs)—Carimas, FlowQuant, and PMOD—to quantify myocardial perfusion at global, regional, and segmental levels. Stress N-13 ammonia PET scans of 48 patients with HCM were analyzed in three centers using Carimas, FlowQuant, and PMOD. Values agreed if they had a...

Full description

Saved in:
Bibliographic Details
Published in:Journal of nuclear cardiology 2022-10, Vol.29 (5), p.2543-2550
Main Authors: Nesterov, Sergey V., Sciagrà, Roberto, Orozco, Luis Eduardo Juarez, Prior, John O., Settimo, Leonardo, Han, Chunlei, Deshayes, Emmanuel, deKemp, Robert A., Ryzhkova, Darja V., Gwet, Kilem L., Knuuti, Juhani M.
Format: Article
Language:English
Subjects:
absolute quantification
agreement
Ammonia
Cardiology
Coronary Circulation
Humans
Imaging
Imaging software
Medicine
Medicine & Public Health
Myocardial Perfusion Imaging
N-13 ammonia
Nuclear Medicine
Original
Original Article
Perfusion
Positron-Emission Tomography
quantitative imaging
Radiology
Reproducibility
Reproducibility of Results
Software
Software packages
standardization of PET
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:To cross-compare three software packages (SPs)—Carimas, FlowQuant, and PMOD—to quantify myocardial perfusion at global, regional, and segmental levels. Stress N-13 ammonia PET scans of 48 patients with HCM were analyzed in three centers using Carimas, FlowQuant, and PMOD. Values agreed if they had an ICC > 0.75 and a difference < 20% of the median across all observers. When using 1TCM on the global level, the agreement was good, and the maximum difference between 1TCM MBF values was 17.2% (ICC = 0.83). On the regional level, the agreement was acceptable except in the LCx region (25.5% difference, ICC = 0.74) between FlowQuant and PMOD. Carimas-1TCM agreed well with PMOD-1TCM and FlowQuant-1TCM. Values obtained with FlowQuant-1TCM had a somewhat lesser agreement with PMOD-1TCM, especially at the segmental level. The global and regional MBF values (with one exception) agree well between the different software packages. There is significant variability in segmental values, mainly located in the LCx region and segments. Out of the studied tools, Carimas can be used interchangeably with both PMOD and FlowQuant for 1TCM implementation on all levels—global, regional, and segmental.
ISSN:1071-3581
1532-6551
DOI:10.1007/s12350-021-02741-4