Role of RAGE in the Pathogenesis of Neurological Disorders

This review reflects upon our own as well as other investigators’ studies on the role of receptor for advanced glycation end-products (RAGE), bringing up the latest information on RAGE in physiology and pathology of the nervous system. Over the last ten years, major progress has been made in uncover...

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Bibliographic Details
Published in:Neuroscience bulletin 2022-10, Vol.38 (10), p.1248-1262
Main Authors: Juranek, Judyta, Mukherjee, Konark, Kordas, Bernard, Załęcki, Michał, Korytko, Agnieszka, Zglejc-Waszak, Kamila, Szuszkiewicz, Jarosław, Banach, Marta
Format: Article
Language:English
Subjects:
Anatomy
Anesthesiology
Biomedical and Life Sciences
Biomedicine
Genetic engineering
Genetically modified organisms
Health aspects
Human Physiology
Nervous system diseases
Neurology
Neurosciences
Pain Medicine
Review
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Summary:This review reflects upon our own as well as other investigators’ studies on the role of receptor for advanced glycation end-products (RAGE), bringing up the latest information on RAGE in physiology and pathology of the nervous system. Over the last ten years, major progress has been made in uncovering many of RAGE-ligand interactions and signaling pathways in nervous tissue; however, the translation of these discoveries into clinical practice has not come to fruition yet. This is likely, in part to be the result of our incomplete understanding of this crucial signaling pathway. Clinical trials examining the therapeutic efficacy of blocking RAGE-external ligand interactions by genetically engineered soluble RAGE or an endogenous RAGE antagonist, has not stood up to its promise; however, other trials with different blocking agents are being considered with hope for therapeutic success in diseases of the nervous system.
ISSN:1673-7067
1995-8218
DOI:10.1007/s12264-022-00878-x