Influence of Age on the Diagnosis of Myocardial Infarction

The 99th centile of cardiac troponin, derived from a healthy reference population, is recommended as the diagnostic threshold for myocardial infarction, but troponin concentrations are strongly influenced by age. Our aim was to assess the diagnostic performance of cardiac troponin in older patients...

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Bibliographic Details
Published in:Circulation (New York, N.Y.) N.Y.), 2022-10, Vol.146 (15), p.1135-1148
Main Authors: Lowry, Matthew T.H., Doudesis, Dimitrios, Wereski, Ryan, Kimenai, Dorien M., Tuck, Christopher, Ferry, Amy V., Bularga, Anda, Taggart, Caelan, Lee, Kuan K., Chapman, Andrew R., Shah, Anoop S.V., Newby, David E., Mills, Nicholas L., Anand, Atul
Format: Article
Language:English
Subjects:
Acute Coronary Syndrome - diagnosis
Aged
Biomarkers
Female
Humans
Male
Myocardial Infarction - diagnosis
Original s
Risk Assessment
Troponin I
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Summary:The 99th centile of cardiac troponin, derived from a healthy reference population, is recommended as the diagnostic threshold for myocardial infarction, but troponin concentrations are strongly influenced by age. Our aim was to assess the diagnostic performance of cardiac troponin in older patients presenting with suspected myocardial infarction. In a secondary analysis of a multicenter trial of consecutive patients with suspected myocardial infarction, we assessed the diagnostic accuracy of high-sensitivity cardiac troponin I at presentation for the diagnosis of type 1, type 2, or type 4b myocardial infarction across 3 age groups (
ISSN:0009-7322
1524-4539
DOI:10.1161/CIRCULATIONAHA.122.059994