Oxidative Stress in Fibromyalgia: From Pathology to Treatment

Fibromyalgia (FM) is characterized by chronic widespread musculoskeletal pain associated with sleep problems, fatigue, depression, and anxiety. The persistence of pain, impairment of cognitive function, and negative impact on the psychological state have caused a detrimental effect on the patients’...

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Bibliographic Details
Published in:Oxidative medicine and cellular longevity 2022-10, Vol.2022, p.1-11
Main Authors: Assavarittirong, Chanika, Samborski, Włodzimierz, Grygiel-Górniak, Bogna
Format: Article
Language:English
Subjects:
Antioxidants
Autophagy
Chronic fatigue syndrome
Chronic illnesses
Enzymes
Exercise
Fibromyalgia
Free radicals
Influence
Lipid peroxidation
Lipids
Melatonin
Nervous system
Neuropeptides
Nitric oxide
Oxidation
Oxidative stress
Pain
Pathogenesis
Quality of life
Review
Sleep
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Summary:Fibromyalgia (FM) is characterized by chronic widespread musculoskeletal pain associated with sleep problems, fatigue, depression, and anxiety. The persistence of pain, impairment of cognitive function, and negative impact on the psychological state have caused a detrimental effect on the patients’ quality of life. However, to date, the treatment and mechanisms of this disease are yet to be established. Oxidative stress might play a critical role in FM pathophysiology. Increased levels of prooxidative factors such as nitric oxide, lipid peroxidation, and mitophagy can cause pain sensitization in fibromyalgia. Numerous studies have supported the hypothesis of beneficial antioxidative effects in FM. Due to the lack of effective therapy for fibromyalgia, many treatments are sought to reduce pain and fatigue and improve patients’ quality of life. This manuscript discusses the impact of various antioxidative procedures that can diminish fibromyalgia symptoms, such as hyperbaric oxygen therapy, modification of dietary habits, and physical activity.
ISSN:1942-0900
1942-0994
DOI:10.1155/2022/1582432