The Effectiveness and Safety of Abelmoschus manihot in Treating IgA Nephropathy: A Systematic Review and Meta-Analysis

Introduction. IgA nephropathy (IgAN) is a common issue. In China, Abelmoschus manihot (AM) is widely used in the treatment of IgAN. However, their combined effectiveness and safety for this purpose have not yet been explored. AM is an effective medicine for treating IgAN. This meta-analysis aimed to...

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Bibliographic Details
Published in:Evidence-based complementary and alternative medicine 2022-10, Vol.2022, p.1-11
Main Authors: Jia, Qi, Guo, Jing, Cai, Yuzi, Huang, Weijun, Zhu, Zebing, Xia, Chenhui, Guo, Keting, Shang, Hongcai, Liu, Yuning, Liu, Weijing
Format: Article
Language:English
Subjects:
Abelmoschus manihot
Bias
Biopsy
Blood pressure
Clinical trials
Creatinine
Endocrine system
IgA nephropathy
Immunoglobulin A
Kidney diseases
Meta-analysis
Potassium
Proteinuria
Review
Safety
Systematic review
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Summary:Introduction. IgA nephropathy (IgAN) is a common issue. In China, Abelmoschus manihot (AM) is widely used in the treatment of IgAN. However, their combined effectiveness and safety for this purpose have not yet been explored. AM is an effective medicine for treating IgAN. This meta-analysis aimed to evaluate the effectiveness of AM for IgAN. Materials and Methods. The Cochrane Library, PubMed, EMBASE, Allied and Complementary Medicine Database (AMED), Chinese Biomedical Literature Database (CBM), Chinese National Knowledge Infrastructure Database (CNKI), Chinese Science and Technique Journals Database (VIP), and the Wanfang Database were searched from their inceptions to June 2021. Random clinical trials (RCTs) comparing the effects of AM treatment in patients with IgAN were included. The study evaluated the efficacy or effectiveness of AM for IgAN and had clear outcome data, such as total effectiveness rate or proteinuria. Results. A total of 11 RCTs with 850 participants were included in this meta-analysis. The results of the meta-analysis showed that, compared with that of the conventional therapy alone, being combined with conventional treatment was significantly more effective for the total efficacy rate (OR = 4.33; 95% CI = 2.66, 7.04; P
ISSN:1741-427X
1741-4288
DOI:10.1155/2022/9730753