Assessment of hepatic fibrosis and inflammation with look-locker T1 mapping and magnetic resonance elastography with histopathology as reference standard

Purpose To compare the diagnostic performance of T1 mapping and MR elastography (MRE) for staging of hepatic fibrosis and grading inflammation with histopathology as standard of reference. Methods 68 patients with various liver diseases undergoing liver biopsy for suspected fibrosis or with an estab...

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Published in:Abdominal imaging 2022-11, Vol.47 (11), p.3746-3757
Main Authors: von Ulmenstein, Sophie, Bogdanovic, Sanja, Honcharova-Biletska, Hanna, Blümel, Sena, Deibel, Ansgar R., Segna, Daniel, Jüngst, Christoph, Weber, Achim, Kuntzen, Thomas, Gubler, Christoph, Reiner, Cäcilia S.
Format: Article
Language:English
Subjects:
Biopsy
Cirrhosis
Diagnostic systems
Elasticity Imaging Techniques - methods
Fibrosis
Gastroenterology
Hepatobiliary
Hepatology
Histopathology
Humans
Imaging
Inflammation
Inflammation - diagnostic imaging
Inflammation - pathology
Liver
Liver - diagnostic imaging
Liver - pathology
Liver cirrhosis
Liver Cirrhosis - diagnostic imaging
Liver Cirrhosis - pathology
Liver diseases
Magnetic resonance
Magnetic Resonance Imaging - methods
Mapping
Medicine
Medicine & Public Health
Radiology
Reference Standards
Relaxation time
Statistical analysis
Stiffness
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Summary:Purpose To compare the diagnostic performance of T1 mapping and MR elastography (MRE) for staging of hepatic fibrosis and grading inflammation with histopathology as standard of reference. Methods 68 patients with various liver diseases undergoing liver biopsy for suspected fibrosis or with an established diagnosis of cirrhosis prospectively underwent look-locker inversion recovery T1 mapping and MRE. T1 relaxation time and liver stiffness (LS) were measured by two readers. Hepatic fibrosis and inflammation were histopathologically staged according to a standardized fibrosis (F0–F4) and inflammation (A0–A2) score. For statistical analysis, independent t test, and Mann–Whitney U test and ROC analysis were performed, the latter to determine the performance of T1 mapping and MRE for fibrosis staging and inflammation grading, as compared to histopathology. Results Histopathological analysis diagnosed 9 patients with F0 (13.2%), 21 with F1 (30.9%), 11 with F2 (16.2%), 10 with F3 (14.7%), and 17 with F4 (25.0%). Both T1 mapping and MRE showed significantly higher values for patients with significant fibrosis (F0-1 vs. F2-4; T1 mapping p  
ISSN:2366-0058
2366-004X
2366-0058
DOI:10.1007/s00261-022-03647-6