Skeletal muscle and related protein expression as prognostic factors in thymic squamous cell carcinoma

Sarcopenia and its marker, the psoas muscle index (PMI), have attracted attention as prognostic factors for various types of cancers. The fragile X-related 1 ( ) gene is highly expressed in myocytes, and FXR1 overexpression is a candidate biomarker for poor survival in several types of cancers. Thym...

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Published in:Journal of thoracic disease 2022-09, Vol.14 (9), p.3245-3254
Main Authors: Nakanishi, Keita, Ozeki, Naoki, Tateyama, Hisashi, Kadomatsu, Yuka, Ueno, Harushi, Goto, Masaki, Nakamura, Shota, Fukumoto, Koichi, Chen-Yoshikawa, Toyofumi Fengshi
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Language:English
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Summary:Sarcopenia and its marker, the psoas muscle index (PMI), have attracted attention as prognostic factors for various types of cancers. The fragile X-related 1 ( ) gene is highly expressed in myocytes, and FXR1 overexpression is a candidate biomarker for poor survival in several types of cancers. Thymic squamous cell carcinoma (TSQCC) is rare, and no studies assessing its prognostic factors, particularly in terms of skeletal muscle mass and FXR1 expression, are available. We retrospectively investigated the prognostic significance of PMI in 34 patients who underwent TSQCC resection, considering the status of FXR1 and tumor programmed death-ligand 1 (PD-L1). PMI was calculated from the bilateral psoas muscle using preoperative computed tomography (CT). Patients were divided into two groups: low PMI (
ISSN:2072-1439
2077-6624
DOI:10.21037/jtd-22-385