Home Environment in Early-Life and Lifestyle Factors Associated with Asthma and Allergic Diseases among Inner-City Children from the REPRO_PL Birth Cohort

• Published in: International journal of environmental research and public health 2022-09, Vol.19 (19), p.11884
• Main Authors: Kapszewicz, Katarzyna, Podlecka, Daniela, Polańska, Kinga, Stelmach, Iwona, Majak, Pawel, Majkowska-Wojciechowska, Barbara, Tymoniuk, Bogusław, Jerzyńska, Joanna, Brzozowska, Agnieszka
• Format: Article
• Language: English
• Subjects: Air flow; Allergens; Allergic diseases; Allergic rhinitis; Allergies; Antibodies; Asthma; Asthma - chemically induced; Asthma - etiology; Atopic dermatitis; Birth Cohort; Children; Children & youth; Childrens health; Cleaning; Clustering; Cotinine; Dermatitis; Dermatitis, Atopic - chemically induced; Dust; Dust - analysis; Eczema; Exposure; Fungi; Hay fever; Health risks; Home Environment; House dust; Houses; Housing conditions; Humans; Hypersensitivity - complications; Hypersensitivity - epidemiology; Inner city; Moisture content; Mothers; Questionnaires; Rhinitis; Risk analysis; Risk factors; Steam; Tobacco; Tobacco smoke; Tobacco Smoke Pollution - adverse effects
• ISSN: 1660-4601; 1661-7827; 1660-4601
• DOI: 10.3390/ijerph191911884

We hypothesized that, in our REPRO_PL cohort, exposure to indoor allergens and lifestyle factors in early life are associated with risk of asthma, atopic dermatitis, and allergic rhinitis at ten years of age. We only examined children who had lived in the same house from birth. Children's exposure to tobacco smoke was assessed based on cotinine levels in urine. House dust samples were collected. Higher Fel d1 concentration in house dust was associated with significantly higher risk of developing asthma at age 10 years (95% CI,10.87 to 20.93; < 0.001). Frequent house cleaning was associated with development of atopic dermatitis (odds ratio 0.61; 95% CI 0.37 to 0.99; = 0.045). Clustering of exposure to HDM revealed two types of environment. Cluster 1, defined as lower HDM (dust), in contrast to Cluster 2, defined as higher HDM, was characterized by old-type windows, lower fungus and dampness levels, as well as more frequent house cleaning. Exposure to cat allergens and new-type buildings that limit air flow while increasing the condensation of steam on the windows and thereby stimulating the growth of fungi are risk factors for the development of asthma.