Radiofrequency Ablation of Indeterminate Thyroid Nodules: The First North American Comparative Analysis

Thyroid nodules can be classified as benign, malignant, or indeterminate, the latter of which make up 10-30% of nodules. Radiofrequency ablation (RFA) has become an attractive and promising therapy for the treatment of benign thyroid nodules. However, few studies have investigated the safety and eff...

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Bibliographic Details
Published in:International journal of molecular sciences 2022-09, Vol.23 (19), p.11493
Main Authors: Issa, Peter P, Omar, Mahmoud, Issa, Chad P, Buti, Yusef, Hussein, Mohammad, Aboueisha, Mohamed, Abdelhady, Ali, Shama, Mohamed, Lee, Grace S, Toraih, Eman, Kandil, Emad
Format: Article
Language:English
Subjects:
Ablation
Benign
Catheter Ablation - adverse effects
Comparative analysis
Humans
Hyperplasia
Nodules
North America
Patients
Radio frequency
Radiofrequency Ablation
Retrospective Studies
Success
Thyroid
Thyroid gland
Thyroid Nodule - diagnosis
Thyroidectomy
Treatment Outcome
Tumors
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Summary:Thyroid nodules can be classified as benign, malignant, or indeterminate, the latter of which make up 10-30% of nodules. Radiofrequency ablation (RFA) has become an attractive and promising therapy for the treatment of benign thyroid nodules. However, few studies have investigated the safety and efficacy of RFA for the management of indeterminate thyroid nodules. In this study, 178 patients with thyroid nodules diagnosed as benign (Bethesda II) or indeterminate (Bethesda III/IV) by preoperative cytopathological analysis were included. Patients in the benign and indeterminate cohorts had similar thyroid nodule volume reduction rates at 65.60% and 64.20%, respectively ( = 0.68). The two groups had similar nodular regrowth rates, at 11.2% for benign nodules and 9.40% for indeterminate nodules ( = 0.72). A total of three cases of transient dysphonia were reported. RFA of indeterminate thyroid nodules was comparable to that of benign thyroid nodules in all parameters of interest, including volume reduction rate. To our best knowledge, our work is the first North American analysis comparing benign and indeterminate thyroid nodules and suggests RFA to be a promising modality for the management of indeterminate thyroid nodules.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms231911493