Perspectives for the Use of Fucoidans in Clinical Oncology

Fucoidans are natural sulfated polysaccharides that have a wide range of biological functions and are regarded as promising antitumor agents. The activity of various fucoidans and their derivatives has been demonstrated in vitro on tumor cells of different histogenesis and in experiments on mice wit...

Full description

Saved in:
Bibliographic Details
Published in:International journal of molecular sciences 2022-10, Vol.23 (19), p.11821
Main Authors: Kiselevskiy, Mikhail V, Anisimova, Natalia Yu, Ustyuzhanina, Nadezhda E, Vinnitskiy, Dmitry Z, Tokatly, Alexandra I, Reshetnikova, Vera V, Chikileva, Irina O, Shubina, Irina Zh, Kirgizov, Kirill I, Nifantiev, Nikolay E
Format: Article
Language:English
Subjects:
Algae
Animals
Anti-Inflammatory Agents
Antiangiogenics
Anticoagulants
Anticoagulants - pharmacology
Anticoagulants - therapeutic use
Antigens
Antitumor activity
Apoptosis
Biopolymers
Cancer
Cancer therapies
Cell cycle
Chemotherapy
Clinical trials
Colorectal cancer
Cytostatic Agents
Cytotoxicity
Drug dosages
Fucoidan
Hematopoiesis
Histogenesis
Immunomodulation
Immunotherapy
Inflammation
Lung cancer
Lymphocytes
Medical Oncology
Metastasis
Mice
Neoplasms - drug therapy
Palliative care
Patients
Polysaccharides
Polysaccharides - pharmacology
Polysaccharides - therapeutic use
Quality of Life
Radiation therapy
Review
Tumor cells
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Fucoidans are natural sulfated polysaccharides that have a wide range of biological functions and are regarded as promising antitumor agents. The activity of various fucoidans and their derivatives has been demonstrated in vitro on tumor cells of different histogenesis and in experiments on mice with grafted tumors. However, these experimental models showed low levels of antitumor activity and clinical trials did not prove that this class of compounds could serve as antitumor drugs. Nevertheless, the anti-inflammatory, antiangiogenic, immunostimulating, and anticoagulant properties of fucoidans, as well as their ability to stimulate hematopoiesis during cytostatic-based antitumor therapy, suggest that effective fucoidan-based drugs could be designed for the supportive care and symptomatic therapy of cancer patients. The use of fucoidans in cancer patients after chemotherapy and radiation therapy might promote the rapid improvement of hematopoiesis, while their anti-inflammatory, immunomodulatory, and anticoagulant effects have the potential to improve the quality of life of patients with advanced cancer.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms231911821