Angioside: The role of Angiogenesis and Hypoxia in Lung Neuroendocrine Tumours According to Primary Tumour Location in Left or Right Parenchyma

• Published in: Journal of clinical medicine 2022-10, Vol.11 (19), p.5958
• Main Authors: La Salvia, Anna, Carletti, Raffaella, Verrico, Monica, Feola, Tiziana, Puliani, Giulia, Bassi, Massimiliano, Sesti, Franz, Pernazza, Angelina, Mazzilli, Rossella, Lamberti, Giuseppe, Siciliani, Alessandra, Mancini, Massimiliano, Manai, Chiara, Venuta, Federico, Ibrahim, Mohsen, Tomao, Silverio, D'Amati, Giulia, Di Gioia, Cira, Giannetta, Elisa, Cappuzzo, Federico, Faggiano, Antongiulio
• Format: Article
• Language: English
• Subjects: Angiogenesis; Antibodies; Cancer; Classification; Clinical medicine; Gene expression; Growth factors; Hypoxia; Kinases; Medical prognosis; Neuroendocrine tumors
• ISSN: 2077-0383; 2077-0383
• DOI: 10.3390/jcm11195958

Well-differentiated lung neuroendocrine tumours (Lu-NETs), classified as typical (TC) and atypical (AC) carcinoids, represent 30% of NETs. Angiogenesis plays an essential role in NET development and progression. A higher vascular network is a marker of differentiation, with positive prognostic implications. Materials and Methods: We retrospectively evaluated microvessel density (MVD) by CD34 immunohistochemical (IHC) staining and hypoxia by IHC staining for Hypoxia-inducible factor 1α (HIF-1α), comparing right- and left-lung parenchyma in 53 lung NETs. Results: The median age was 66 years (39−81), 56.6% males, 24.5% AC, 40.5% left-sided tumours and 69.8% TNM stage I. The mitotic count was