A Rare Case of Neurosarcoidosis Overlapped with Sjogren’s Syndrome

The coexisting of sarcoidosis and Sjögren’s syndrome (SS) has long been neglected since sarcoidosis is considered as an exclusion criterion for SS. We described a 55-year-old woman, who was diagnosed with coexisting neurosarcoidosis and Sjögren’s syndrome for 16 years. She presented with erythema no...

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Bibliographic Details
Published in:Journal of clinical medicine 2022-10, Vol.11 (19), p.5709
Main Authors: Cai, Wenxin, Li, Ru, He, Jing, Shao, Miao, Li, Zhanguo
Format: Article
Language:English
Subjects:
Antibodies
Biopsy
Bronchoscopy
Case Report
Clinical medicine
Disease
Erythema
Exocrine glands
Granulomas
Immunotherapy
Laboratories
Lavage
Lymphatic system
Lymphocytes
Magnetic resonance imaging
Monoclonal antibodies
Muscle strength
Nervous system
Patients
Sarcoidosis
Spinal cord
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Summary:The coexisting of sarcoidosis and Sjögren’s syndrome (SS) has long been neglected since sarcoidosis is considered as an exclusion criterion for SS. We described a 55-year-old woman, who was diagnosed with coexisting neurosarcoidosis and Sjögren’s syndrome for 16 years. She presented with erythema nodosum, progressive sensory and motor impairment of the extremities, dry mouth, and dry eyes. High-resolution computed tomography (HRCT) of the chest showed symmetrical pulmonary micronodules, interstitial changes, and enlarged mediastinal lymph nodes. Spine magnetic resonance imaging (MRI) showed syringomyelia and thickening of the T3-9 spinal cord. She was with positive ANA and anti-SSA antibodies, impaired function of the lacrimal, salivary gland and renal tubules. Biopsy of skin and lung nodules revealed non-caseous granuloma. Salivary gland biopsy showed focal lymphocyte infiltration. Classification criteria for sarcoidosis and Sjogren’s syndrome were fulfilled in this patient based on clinical and laboratory features. This case extends our understanding of overlapped Sjogren’s syndrome with sarcoidosis and provides a referential value for clinical diagnosis.
ISSN:2077-0383
2077-0383
DOI:10.3390/jcm11195709