Antioxidative and Photo-Induced Effects of Different Types of N-Doped Graphene Quantum Dots

Due to the increasing number of bacterial infections and the development of resistivity toward antibiotics, new materials and approaches for treatments must be urgently developed. The production of new materials should be ecologically friendly considering overall pollution with chemicals and economi...

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Bibliographic Details
Published in:Materials 2022-09, Vol.15 (19), p.6525
Main Authors: Jovanovic, Svetlana, Bonasera, Aurelio, Dorontic, Sladjana, Zmejkoski, Danica, Milivojevic, Dusan, Janakiev, Tamara, Todorovic Markovic, Biljana
Format: Article
Language:English
Subjects:
Active oxygen
Analysis
Antibiotics
Antiinfectives and antibacterials
Biocompatibility
Discoloration
Functional groups
Gamma irradiation
Gamma rays
Graphene
Graphite
Light irradiation
Morphology
Photodynamic therapy
Photoluminescence
Potassium permanganate
Pseudomonas aeruginosa
Quantum dots
Reagents
Singlet oxygen
Software
Spectrum analysis
Transmission electron microscopy
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Summary:Due to the increasing number of bacterial infections and the development of resistivity toward antibiotics, new materials and approaches for treatments must be urgently developed. The production of new materials should be ecologically friendly considering overall pollution with chemicals and economically acceptable and accessible to the wide population. Thus, the possibility of using biocompatible graphene quantum dots (GQDs) as an agent in photodynamic therapy was studied. First, dots were obtained using electrochemical cutting of graphite. In only one synthetic step using gamma irradiation, GQDs were doped with N atoms without any reagent. Obtained dots showed blue photoluminescence, with a diameter of 19-89 nm and optical band gap of 3.23-4.73 eV, featuring oxygen-containing, amino, and amide functional groups. Dots showed antioxidative activity; they quenched •OH at a concentration of 10 μg·mL , scavenged DPPH• radicals even at 5 μg·mL , and caused discoloration of KMnO at 30 μg·mL . Under light irradiation, dots were able to produce singlet oxygen, which remained stable for 10 min. Photoinduced effects by GQDs were studied on several bacterial strains ( , , clinical strains of , , and , , and one yeast strain ) but antibacterial effects were not noticed.
ISSN:1996-1944
1996-1944
DOI:10.3390/ma15196525