Intra Articular Injection of Autologous Microfat and Platelets-Rich Plasma in the Treatment of Wrist Osteoarthritis: A Pilot Study

No injection treatment has been proven to be effective in wrist osteoarthritis. When conservative measures fail, its management involves invasive surgery. Emergence of biotherapies based on adipose derived stem cells (ADSC) offers promising treatments for chondral degenerative diseases. Microfat (MF...

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Published in:Journal of clinical medicine 2022-09, Vol.11 (19), p.5786
Main Authors: Mayoly, Alice, Witters, Marie, Jouve, Elisabeth, Bec, Cécilia, Iniesta, Aurélie, Kachouh, Najib, Veran, Julie, Grimaud, Fanny, Zavarro, Anouck Coulange, Fernandez, Rémi, Bendahan, David, Giraudo, Laurent, Dumoulin, Chloé, Chagnaud, Christophe, Casanova, Dominique, Sabatier, Florence, Legré, Régis, Jaloux, Charlotte, Magalon, Jérémy
Format: Article
Language:English
Subjects:
Arthritis
Automation
Biotechnology
Blood
Blood platelets
Body fat
Cartilage
Clinical medicine
Cytokines
Growth factors
Hospitals
Human health and pathology
Life Sciences
Local anesthesia
Osteoarthritis
Plasma
Reconstructive surgery
Rhumatology and musculoskeletal system
Stem cells
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Summary:No injection treatment has been proven to be effective in wrist osteoarthritis. When conservative measures fail, its management involves invasive surgery. Emergence of biotherapies based on adipose derived stem cells (ADSC) offers promising treatments for chondral degenerative diseases. Microfat (MF) and platelets-rich plasma (PRP) mixture, rich in growth factors and ADSC could be a minimally invasive injectable option in the treatment of wrist osteoarthritis. The aim of this uncontrolled prospective study was to evaluate the safety of a 4 mL autologous MF-PRP intra-articular injection, performed under local anesthesia. The secondary purpose was to describe the clinical and MRI results at 12 months of follow-up. Patients' data collected were: occurrence of adverse effects, Visual analog scale (VAS), Disabilities of the Arm, Shoulder and Hand score (DASH) and Patient-Rated Wrist Evaluation (PRWE) scores, wrist strength, wrist range of motion and 5-level satisfaction scale. No serious adverse event was recorded. A statistically significant decrease in pain, DASH, PRWE and force was observed at each follow-up. Our preliminary results suggest that intra-articular autologous MF and PRP injection may be a new therapeutic strategy for wrist osteoarthritis resistant to medical symptomatic treatment prior to surgical interventions.
ISSN:2077-0383
2077-0383
DOI:10.3390/jcm11195786