Isinglass Polysaccharides Regulate Intestinal-Barrier Function and Alleviate Obesity in High-Fat Diet Mice through the HO-1/Nrf2 Pathway and Intestinal Microbiome Environment

Plant polysaccharide intervention has shown significant potential to combat obesity. However, studies on animal polysaccharides are indeed rare. The aim of this study was to investigate the potential functions of CIP (IL) on obesity, intestinal microflora dysbiosis, and the possible protection of in...

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Bibliographic Details
Published in:Nutrients 2022-09, Vol.14 (19), p.3928
Main Authors: Li, Guopeng, Li, Shugang, Liu, Huanhuan, Zhang, Lihua, Gao, Jingzhu, Zhang, Siteng, Zou, Yue, Xia, Xiaodong, Ren, Xiaomeng
Format: Article
Language:English
Subjects:
Accumulation
Bioengineering
Body fat
Body weight loss
Calories
Cardiovascular disease
Cholesterol
Cytokines
Diet
Dysbacteriosis
Experiments
Functional foods
Functional foods & nutraceuticals
Gene expression
High fat diet
Homeostasis
Inflammation
Intestinal microflora
Intestine
Isinglass
Lipid metabolism
Lipids
Liver
Metabolism
Metabolites
Microbiomes
Microbiota
Microbiota (Symbiotic organisms)
mRNA
Obesity
Polysaccharides
Proteins
Public health
RNA
Saccharides
Tumor necrosis factor-TNF
Type 2 diabetes
Weight loss
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Summary:Plant polysaccharide intervention has shown significant potential to combat obesity. However, studies on animal polysaccharides are indeed rare. The aim of this study was to investigate the potential functions of CIP (IL) on obesity, intestinal microflora dysbiosis, and the possible protection of intestinal barrier in mice fed with high-fat diet (HFD). Our results revealed that after 13 weeks, the HFD+L (high-fat diet + 25 mg/kg CIP) group showed significantly more weight loss and fat accumulation relative to the HFD+H (high-fat diet + 50 mg/kg CIP) group. Furthermore, CIP intervention modulated lipid metabolism and mRNA levels of inflammatory mediators in liver. Overall, CIP clearly improved the intestinal barrier in HFD-fed mice. Additionally, we observed that CIP intervention improved intestinal microbiota community richness and diversity in HFD-fed mice. The CIP intervention mice group showed a relatively low Firmicutes to Bacteroidetes ratio compared to the HFD group. This study concluded that CIP could be used as a functional food to prevent adipocyte accumulation, reduce systemic inflammation, and protect the intestinal barrier.
ISSN:2072-6643
2072-6643
DOI:10.3390/nu14193928