Impact of frailty on mortality and quality of life in patients with a history of cancer undergoing transcatheter aortic valve replacement

Background: Transcatheter aortic valve replacement (TAVR) is increasingly offered for aortic stenosis (AS) treatment in patients with a history of cancer. The impact of frailty on outcomes in this specific patient population is not well described. Hypothesis: Frailty is associated with mortality and...

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Published in:Clinical cardiology (Mahwah, N.J.) N.J.), 2022-10, Vol.45 (10), p.977-985
Main Authors: Kosaraju, Nikitha, Wu, Perry, Leng, Mei, Bolano, Marielle, Rafique, Asim M, Shen, John, Satou, Nancy, Huchting, Jeanne, Goldwater, Deena, Aksoy, Olcay, Yang, Eric H
Format: Article
Language:English
Subjects:
Activities of daily living
Albumin
Analysis
Aortic stenosis
Aortic valve stenosis
Cancer
Cancer patients
Cancer therapies
Cardiomyopathy
Clinical Trial Result
Cognitive ability
Electronic health records
Frailty
Gait
Heart
Hemoglobin
Mortality
Oncology, Experimental
Patient outcomes
Patients
Quality of life
Questionnaires
Remission (Medicine)
Surgeons
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Summary:Background: Transcatheter aortic valve replacement (TAVR) is increasingly offered for aortic stenosis (AS) treatment in patients with a history of cancer. The impact of frailty on outcomes in this specific patient population is not well described. Hypothesis: Frailty is associated with mortality and poorer quality of life (QOL) outcomes in patients undergoing TAVR with a history of cancer. Methods: This retrospective single center cohort study included AS patients who underwent TAVR from August 1, 2012 to May 15, 2020. Frailty was measured using serum albumin, hemoglobin, gait speed, functional dependence, and cognitive impairment. The primary outcome was a composite of all-cause mortality and QOL at 1 year. A poor primary outcome was defined as either all-cause mortality, Kansas City Cardiomyopathy Questionnaire overall summary (KCCQ-OS) score
ISSN:0160-9289
1932-8737
DOI:10.1002/clc.23927