Lagerstroemia speciosa Ameliorated Blood Pressure in LNAME Induced Hypertension in Experimental Rats through NO/cGMP and Oxidative Stress Modulation

Cardiovascular disease is the primary reason for chronic heart diseases and mortality worldwide. Hypertension (HTN) is the utmost dominant risk factor for the evolution of several diseases. Herbal medicines, traditional medicinal herbs, and their extracts are widely utilized to treat and monitor HTN...

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Bibliographic Details
Published in:BioMed research international 2022-10, Vol.2022, p.5894416-8
Main Authors: Aleissa, Mohammed S., Al-Zharani, Mohammed, Alneghery, Lina M., Hasnain, Md Saquib, Almutairi, Bader, Ali, Daoud, Alarifi, Saud, Alkahtani, Saad
Format: Article
Language:English
Subjects:
Animals
Antihypertensives
Antioxidants
Arteries
Bioavailability
Blood circulation
Blood Pressure
Body weight
Cardiovascular disease
Cardiovascular diseases
Care and treatment
Chemical properties
Coronary artery disease
Cyclic GMP
Cytokines
Development and progression
Diabetes
Drinking water
Enzymes
Flavonoids
Gene expression
Glutathione
Health aspects
Health services
Heart diseases
Heart failure
Hemodynamics
Herbal medicine
Hypertension
Hypertrophy
Inflammation
Lagerstroemia
Lagerstroemia speciosa
Markers
Materia medica, Vegetable
Measurement techniques
Medicinal herbs
Medicinal plants
Nitric oxide
Oxidative Stress
Physiological aspects
Physiology
Plant extracts
Plant Extracts - pharmacology
Plants, Medicinal
Rats
Risk analysis
Risk factors
Rosidae
Water
Weight reduction
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Summary:Cardiovascular disease is the primary reason for chronic heart diseases and mortality worldwide. Hypertension (HTN) is the utmost dominant risk factor for the evolution of several diseases. Herbal medicines, traditional medicinal herbs, and their extracts are widely utilized to treat and monitor HTN. Herbal components have been shown to help relax arteries and lower oxidative stress. The current study assesses the probable role of herbal plant extract Lagerstroemia speciosa (LS) in the LNAME induced HTN in rats. LNAME (50 mg/100 mL) in drinkable water was given to rats for five weeks. There was a significant upsurge in LNAME-treated hypertensive rats’ blood pressure (BP). On treatment with LS, it ameliorates blood pressure. Further, LS also improved body weight, reduced heart weight, and heart hypertrophy. The NO/cGMP concentration was lowered along with a substantial upsurge in the level of glutathione and a decline in MDA level. The LS extract also reduced the inflammatory cytokine markers in the systemic circulation. In conclusion, thus, the extract of LS treatment can efficiently alleviate the BP, oxidative stress markers, and inflammation and improve NO/cGMP concentration in LNAME induced HTN in rats.
ISSN:2314-6133
2314-6141
DOI:10.1155/2022/5894416