Epigenetic changes associated with mechanisms of disparities in hepatocellular carcinoma

In addition to socioeconomic influences, biological factors are believed to play a role in health disparities. In this paper, we investigate miRNA, mRNA, and DNA methylation patterns that contribute to disparities in hepatocellular carcinoma (HCC). This is accomplished by integration of mRNA-Seq, mi...

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Bibliographic Details
Main Authors: Varghese, Rency S., Zhou, Yuan, Chen, Yifan, Barefoot, Megan E., Tadesse, Mahlet, Ressom, Habtom W.
Format: Conference Proceeding
Language:English
Subjects:
ANOVA
DNA methylation
HCC
miRNA-Seq
mRNA-Seq
racial disparity
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Summary:In addition to socioeconomic influences, biological factors are believed to play a role in health disparities. In this paper, we investigate miRNA, mRNA, and DNA methylation patterns that contribute to disparities in hepatocellular carcinoma (HCC). This is accomplished by integration of mRNA-Seq, miRNA-Seq, and DNA methylation data we acquired by analysis of liver tissues from 30 HCC patients consisting of European Americans (EAs), African Americans (AAs), and Asian Americans (Asians). Mixed-ANOVA models are applied to identify miRNAs, mRNAs, and DNA methylation sites that are significantly altered in tumor vs. adjacent normal tissues in a race-specific manner. Through integrated analysis, a refined list of differentially expressed mRNAs is obtained by selecting those that are targets of differentially expressed miRNAs and consist of promoter regions that are differentially methylated.
ISSN:2375-7477
1558-4615
2694-0604
DOI:10.1109/EMBC44109.2020.9176036