Potential mechanisms underlying the association between type II diabetes mellitus and cognitive dysfunction in rats: a link between miRNA-21 and Resveratrol’s neuroprotective action

Cognitive impairment is considered as a typical feature of neurodegenerative diseases in diabetes mellitus (DM). However, the exact link between cognitive dysfunction and diabetes mellitus is still vague. This study aims to investigate some of the mechanisms underlying cognitive impairment that asso...

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Bibliographic Details
Published in:Metabolic brain disease 2022-10, Vol.37 (7), p.2375-2388
Main Authors: El-Sayed, Norhan S., Elatrebi, Soha, Said, Rasha, Ibrahim, Heba F., Omar, Eman M.
Format: Article
Language:English
Subjects:
Bioactive compounds
Biochemistry
Biological activity
Biomedical and Life Sciences
Biomedicine
Brain
Cognitive ability
Diabetes
Diabetes mellitus
Diabetes mellitus (non-insulin dependent)
High fat diet
Hippocampus
Impairment
Insulin
Insulin resistance
Lipids
Metabolic Diseases
miRNA
Neurodegenerative diseases
Neurology
Neuroprotection
Neurosciences
Oncology
Original
Original Article
Oxidative stress
Resveratrol
Signaling
Streptozocin
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Summary:Cognitive impairment is considered as a typical feature of neurodegenerative diseases in diabetes mellitus (DM). However, the exact link between cognitive dysfunction and diabetes mellitus is still vague. This study aims to investigate some of the mechanisms underlying cognitive impairment that associates diabetes mellitus and insulin resistance. We investigated the role of resveratrol as well on cognitive function in experimentally induced type 2 diabetes highlighting on its influence on the expression of brain miRNA 21. Resveratrol is a naturally occurring, biologically active compound that has numerous significant impacts on the body. Type 2 diabetes mellitus was induced by high fat diet followed a single dose of streptozotocin. Diabetic rats were treated with resveratrol for four weeks. Rats were sacrificed after neurobehavioral testing. Hippocampal tissues were used to assess expression of miRNA 21, GSK and oxidative stress markers. Serum samples were obtained to determine glucose levels, lipid profile and insulin levels. Hippocampal and serum AGEs were measured as well and HOMA IR was calculated. We detected memory impairment and disturbed insulin signaling in diabetic rats. These derangements were reversed by resveratrol treatment partially due to increased expression of miRNA-21. Our study pins the role of miRNA-21 in modulating brain insulin signaling and hence alleviating cognitive dysfunction accompanying diabetes mellitus.
ISSN:0885-7490
1573-7365
DOI:10.1007/s11011-022-01035-z