The Value of MRI Combined with AFP, AFP-L3, GP73, and DCP in the Diagnosis of Early Primary Liver Cancer

Objective. To investigate the diagnostic value of magnetic resonance imaging (MRI) combined with serum alpha-fetoprotein (AFP), alpha-fetoprotein (AFP-L3), Golgi protein 73 (GP73), and des-γ-carboxyprothrombin (DCP) on early-stage primary liver cancer (PHC). Methods. A total of 122 patients who were...

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Bibliographic Details
Published in:Disease markers 2022, Vol.2022, p.8640999-5
Main Authors: Kang, Zhongjing, Jin, Kai, Jing, Junpeng
Format: Article
Language:English
Subjects:
alpha-Fetoproteins - metabolism
Biomarkers
Biomarkers, Tumor
Biotechnology
Carcinoma, Hepatocellular - pathology
Diagnosis
Diagnostic systems
Golgi apparatus
Humans
Liver
Liver cancer
Liver diseases
Liver Neoplasms - diagnostic imaging
Liver Neoplasms - metabolism
Magnetic Resonance Imaging
Markers
Membrane Proteins
Parameter sensitivity
Patients
Tumor markers
Tumors
α-Fetoprotein
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Summary:Objective. To investigate the diagnostic value of magnetic resonance imaging (MRI) combined with serum alpha-fetoprotein (AFP), alpha-fetoprotein (AFP-L3), Golgi protein 73 (GP73), and des-γ-carboxyprothrombin (DCP) on early-stage primary liver cancer (PHC). Methods. A total of 122 patients who were treated in our hospital from January 2019 to May 2022 were included in this study, including 62 patients with early PHC (referred to as the observation group) and 60 patients with benign liver disease (referred to as the control group). MRI scans were performed on all participants, and MRI image features were compared. Subsequently, the differences in serum AFP, AFP-L3, GP73, and DCP concentrations of the two groups of patients were detected and compared. Receiver operating characteristic (ROC) curve was used to analyze the efficacy of MRI and each of the above tumor markers in diagnosing early PHC. Results. The proportion of low or slightly low signal on T1WI in the observation group was significantly greater than that in the control group, while the proportions of equisignal and high signal were lower than those in the control group. The proportion of high signal on T2WI and high signal on DWI in the observation group was higher than that in the control group, while the proportion of low or slightly low signal and equisignal was lower than that in the control group. Compared with the control group, the serum concentrations of AFP, AFP-L3, GP73, and DCP in the observation group were significantly increased (all P
ISSN:0278-0240
1875-8630
DOI:10.1155/2022/8640999