Adaptive processing and perceptual learning in visual cortical areas V1 and V4

• Published in: Proceedings of the National Academy of Sciences - PNAS 2022-10, Vol.119 (42), p.1-10
• Main Authors: Astorga, Guadalupe, Chen, Minggui, Altavini, Tiago Siebert, Jiang, Caroline S., Li, Wu, Gilbert, Charles
• Format: Article
• Language: English
• Subjects: Biological Sciences; Learning; Learning - physiology; Neurons; Neurons - physiology; Photic Stimulation; Receptive field; Selectivity; Visual cortex; Visual Cortex - physiology; Visual discrimination learning; Visual Perception - physiology; Visual stimuli; Visual tasks
• ISSN: 0027-8424; 1091-6490
• DOI: 10.1073/pnas.2213080119

Neurons in visual cortical areas primary visual cortex (V1) and V4 are adaptive processors, influenced by perceptual task. This is reflected in their ability to segment the visual scene into task-relevant and task-irrelevant stimulus components and by changing their tuning to task-relevant stimulus properties according to the current top-down instruction. Differences between the information represented in each area were seen. While V1 represented detailed stimulus characteristics, V4 filtered the input from V1 to carry the binary information required for the two-alternative judgement task. Neurons in V1 were activated at locations where the behaviorally relevant stimulus was placed well outside the grating-mapped receptive field. By systematically following the development of the task-dependent signals over the course of perceptual learning, we found that neuronal selectivity for task-relevant information was initially seen in V4 and, over a period of weeks, subsequently in V1. Once the learned information was represented in V1, on any given trial, task-relevant information appeared initially in V1 responses, followed by a 12-ms delay in V4.We propose that the shifting representation of learned information constitutes a mechanism for systems consolidation of memory.