Rare prenylated isoflavonoids from the young twigs of Millettia extensa and their cytotoxic activities

Three new isoflavonoids, millexatins N-P (1-3), along with seven known compounds (6-10), were isolated from the acetone extract of the young twigs of . The structures were characterized by NMR spectroscopic and mass spectrometric analyses. Millexatin N (1) is an unusual geminal diisoprenylated isofl...

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Bibliographic Details
Published in:RSC advances 2022-10, Vol.12 (47), p.30359-30364
Main Authors: Cheenpracha, Sarot, Chokchaisiri, Ratchanaporn, Laphookhieo, Surat, Limtharakul, Thunwadee, Thepmalee, Chutamas
Format: Article
Language:English
Subjects:
Chemistry
Isoflavones
Metabolites
NMR
Nuclear magnetic resonance
Spectrometry
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Summary:Three new isoflavonoids, millexatins N-P (1-3), along with seven known compounds (6-10), were isolated from the acetone extract of the young twigs of . The structures were characterized by NMR spectroscopic and mass spectrometric analyses. Millexatin N (1) is an unusual geminal diisoprenylated isoflavone with a modified ring A. Millexatin P (3) is an unusual isoflavone with a cyclohexyl substituent on ring B, which is extremely rare in nature. The isolated metabolites (1, 2, and 6-10) were evaluated for cytotoxicities against MDA-MB231, Huh-7, KKU-100 and normal human dermal fibroblast (NHDF) cell lines. Only compounds 1, 6 and 8 showed cytotoxicities against all cell lines with IC values ranging from 13.9 to 30.9 μM.
ISSN:2046-2069
2046-2069
DOI:10.1039/d2ra05950a