Assessment of Cystatin C Level for Risk Stratification in Adults With Chronic Kidney Disease

Kidney function is usually estimated from serum creatinine level, whereas an alternative glomerular filtration marker (cystatin C level) associates more closely with future risk of cardiovascular disease (CVD) and mortality. To evaluate whether testing concordance between estimated glomerular filtra...

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Bibliographic Details
Published in:JAMA network open 2022-10, Vol.5 (10), p.e2238300
Main Authors: Lees, Jennifer S, Rutherford, Elaine, Stevens, Kathryn I, Chen, Debbie C, Scherzer, Rebecca, Estrella, Michelle M, Sullivan, Michael K, Ebert, Natalie, Mark, Patrick B, Shlipak, Michael G
Format: Article
Language:English
Subjects:
Age
Aged
Albumins
Cardiovascular Diseases - epidemiology
Cohort Studies
Creatinine
Cystatin C
Female
Humans
Kidney diseases
Male
Middle Aged
Mortality
Nephrology
Older people
Online Only
Original Investigation
Prospective Studies
Renal Insufficiency, Chronic
Risk Assessment
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Summary:Kidney function is usually estimated from serum creatinine level, whereas an alternative glomerular filtration marker (cystatin C level) associates more closely with future risk of cardiovascular disease (CVD) and mortality. To evaluate whether testing concordance between estimated glomerular filtration rates based on cystatin C (eGFRcys) and creatinine (eGFRcr) levels would improve risk stratification for future outcomes and whether estimations differ by age. A prospective population-based cohort study (UK Biobank), with participants recruited between 2006-2010 with median follow-up of 11.5 (IQR, 10.8-12.2) years; data were collected until August 31, 2020. Participants had eGFRcr greater than or equal to 45 mL/min/1.73 m2, albuminuria (albumin
ISSN:2574-3805
2574-3805
DOI:10.1001/jamanetworkopen.2022.38300