SCUBE1 is associated with thrombotic complications, disease severity, and in-hospital mortality in COVID-19 patients

COVID-19 disease, which has recently become an important cause of mortality and morbidity all over the world, is remarkably associated with thrombotic complications. Although many factors are responsible for these increased thrombotic complications in COVID-19 disease, its relationship with a marker...

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Bibliographic Details
Published in:Thrombosis research 2022-12, Vol.220, p.100-106
Main Authors: Toprak, Kenan, Kaplangoray, Mustafa, Palice, Ali, Taşcanov, Mustafa Begenç, İnanır, Mehmet, Memioğlu, Tolga, Kök, Zafer, Biçer, Asuman, Demirbağ, Recep
Format: Article
Language:English
Subjects:
Calcium-Binding Proteins
COVID-19
COVID-19 - complications
Hospital Mortality
Humans
In-hospital mortality
Plasma
SCUBE1
Severity of Illness Index
Thrombosis - etiology
Thrombotic complications
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Summary:COVID-19 disease, which has recently become an important cause of mortality and morbidity all over the world, is remarkably associated with thrombotic complications. Although many factors are responsible for these increased thrombotic complications in COVID-19 disease, its relationship with a marker that increases the risk of thrombosis such as Signal peptide-CUB-EGF domain-containing protein 1 (SCUBE1) has not yet been clarified. This is the first study to examine the potential diagnostic and prognostic value of SCUBE1 levels in patients with COVID-19. In this study, we aimed to clarify the relationship between the increased risk of thrombosis and SCUBE1 in the course of COVID-19 disease. 553 patients with COVID-19 and 553 healthy controls were compared in terms of SCUBE1 levels. Additionally, patients with COVID-19 were divided into two groups according to their SCUBE1 levels and compared in terms of severity of disease, thrombotic complications and ın-hospital mortality. SCUBE1 levels were significantly higher in patients with COVID-19 compared to the control group (p 
ISSN:0049-3848
1879-2472
DOI:10.1016/j.thromres.2022.10.016