Cytoskeletal Protein Palladin in Adult Gliomas Predicts Disease Incidence, Progression, and Prognosis

Brain tumors comprise over 100 types of masses, differing in the following: location; patient age; molecular, histological, and immunohistochemical characteristics; and prognosis and treatment. Glioma tumors originate from neuroglia, cells supporting the brain. Palladin, a structural protein widely...

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Bibliographic Details
Published in:Cancers 2022-10, Vol.14 (20), p.5130
Main Authors: Mayer, Ori, Bugis, Joshua, Kozlova, Daria, Leemann, Aviv, Mansur, Shahar, Peerutin, Ilan, Mendelovich, Noga, Mazin, Meital, Friedmann-Morvinski, Dinorah, Shomron, Noam
Format: Article
Language:English
Subjects:
Antibodies
Apoptosis
Brain cancer
Brain tumors
Breast
Cancer therapies
Cell cycle
Cell differentiation
Cellular proteins
Central nervous system
Chemotherapy
Cytoskeleton
Datasets
Dehydrogenases
Development and progression
Diagnosis
Embryogenesis
Gene expression
Glia
Glioblastoma
Glioma cells
Gliomas
Growth factors
Health aspects
Medical prognosis
Metastasis
Mutation
Pancreas
Prognosis
Proteins
Survival analysis
Therapeutic targets
Tumors
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Summary:Brain tumors comprise over 100 types of masses, differing in the following: location; patient age; molecular, histological, and immunohistochemical characteristics; and prognosis and treatment. Glioma tumors originate from neuroglia, cells supporting the brain. Palladin, a structural protein widely expressed in mammalian tissues, has a pivotal role in cytoskeletal dynamics and motility in health and disease. Palladin is linked to the progression of breast, pancreatic, and renal cancers. In the central nervous system, palladin is involved in embryonic development, neuronal maturation, the cell cycle, differentiation, and apoptosis. However, the role of palladin in brain tumors is unknown. In this work, we explored palladin’s role in glioma. We analyzed clinical data, along with bulk and single-cell gene expression. We then validated our results using IHC staining of tumor samples, together with qRT-PCR of glioma cell lines. We determined that wild-type palladin-4 is overexpressed in adult gliomas and is correlated with a decrease in survival. Palladin expression outperformed clinically used prognostic markers and was most prominent in glioblastoma. Finally, we showed that palladin originates from the malignant cell population. Our findings indicate that palladin expression might be linked to adult glioma progression and is associated with prognosis.
ISSN:2072-6694
2072-6694
DOI:10.3390/cancers14205130