Changes in Tear Proteomic Profile in Ocular Diseases

The search for proteomic biomarkers in ocular disease is one of the most important research directions in recent years. Reliable biomarkers can be an immense adjuvant for both diagnostic and therapeutic approaches. There is no more readily available ocular tissue for proteomic analysis than tear fil...

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Bibliographic Details
Published in:International journal of environmental research and public health 2022-10, Vol.19 (20), p.13341
Main Authors: Winiarczyk, Mateusz, Biela, Katarzyna, Michalak, Katarzyna, Winiarczyk, Dagmara, Mackiewicz, Jerzy
Format: Article
Language:English
Subjects:
Biomarkers
Biomarkers - analysis
Cellulose acetate
Diagnostic systems
Dry Eye Syndromes
Eye
Floods
Glaucoma
Humans
Lipids
Lipids - analysis
Macular degeneration
Measurement methods
Methods
Permeability
Proteins
Proteomics
Proteomics - methods
Review
Sodium
Spectrometry
Tears
Tissue analysis
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Summary:The search for proteomic biomarkers in ocular disease is one of the most important research directions in recent years. Reliable biomarkers can be an immense adjuvant for both diagnostic and therapeutic approaches. There is no more readily available ocular tissue for proteomic analysis than tear film, which makes an interesting target for the biomarker search. Tear film is a complex fluid consisting of a superficial lipid layer, which covers the aqueous-mucous layer. Its complexity makes it a perfect candidate for all the "omics" approaches. Glaucoma, cataract, age-related macular degeneration, and other diseases are commonly thought to have a multifactorial background. Currently, no reliable non-invasive tests are available that would help physicians with screening and further patient management. The aim of the study is to present modern methods of measuring biomarkers in tears, with particular emphasis on spectrometric methods, and to discuss their diagnostic and therapeutic usefulness.
ISSN:1660-4601
1661-7827
1660-4601
DOI:10.3390/ijerph192013341