Parkinsonism-Hyperpyrexia Syndrome: A Case Series and Literature Review

Parkinsonism-hyperpyrexia syndrome (PHS) is a rare, potentially fatal neurological emergency, that is seen in Parkinson’s Disease (PD) patients and mimics neuroleptic malignant syndrome. The most common trigger for PHS is sudden withdrawal of anti-parkinsonian medications, specifically levodopa. How...

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Bibliographic Details
Published in:Curēus (Palo Alto, CA) CA), 2022-09, Vol.14 (9)
Main Authors: Azar, Jehad, Jaber, Yasmin, Ayyad, Mohammed, Abu alia, Walaa, Owda, Fahed, Sharabati, Haneen, Zeid, Hiba, Khreshi, Suleiman, AlBandak, Maram, Sayyed Ahmad, Dana
Format: Article
Language:English
Subjects:
Internal Medicine
Medical Education
Neurology
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Summary:Parkinsonism-hyperpyrexia syndrome (PHS) is a rare, potentially fatal neurological emergency, that is seen in Parkinson’s Disease (PD) patients and mimics neuroleptic malignant syndrome. The most common trigger for PHS is sudden withdrawal of anti-parkinsonian medications, specifically levodopa. However, it can also be due to Deep Brain Stimulation (DBS) device malfunction. In this work, we describe three cases of PHS; the first of which is related to DBS battery depletion, and the remaining two to dopaminergic withdrawal. Additionally, we will include the results of a literature review on PHS, its etiologies, presentation, and management.
ISSN:2168-8184
2168-8184
DOI:10.7759/cureus.29646