Heavy chain constant region usage in antibodies to peptidylarginine deiminase 4 distinguishes disease subsets in rheumatoid arthritis

The study of autoantibody isotypes in autoimmune diseases has been useful for identifying clinically relevant endotypes. Here, we studied the prevalence and clinical significance of different isotypes and IgG subclasses of anti-peptidylarginine deiminase 4 (PAD4) autoantibodies in individuals with r...

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Bibliographic Details
Published in:Arthritis & rheumatology (Hoboken, N.J.) N.J.), 2022-09, Vol.74 (11), p.1746-1754
Main Authors: Gómez-Bañuelos, E, Shi, J, Wang, H, Danila, M I, Bridges, Jr, S L, Giles, J T, Sims, G P, Andrade, F, Darrah, E
Format: Article
Language:English
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Summary:The study of autoantibody isotypes in autoimmune diseases has been useful for identifying clinically relevant endotypes. Here, we studied the prevalence and clinical significance of different isotypes and IgG subclasses of anti-peptidylarginine deiminase 4 (PAD4) autoantibodies in individuals with rheumatoid arthritis (RA). Anti-PAD4 antibody types were determined by ELISA in 196 RA subjects and 64 healthy controls. We investigated associations of anti-PAD4 antibodies and clinical outcomes. Relevant features were confirmed using an independent RA cohort. Anti-PAD4 IgG1, IgG2, IgG3, IgG4, IgA, and IgE antibodies were more frequent in patients with RA than healthy controls (P
ISSN:2326-5191
2326-5205
DOI:10.1002/art.42262