Dose-dependent seizure control with MEK inhibitor therapy for progressive glioma in a child with neurofibromatosis type 1

Background Low-grade gliomas (LGGs) occurring in children can result in many different neurologic complications, including seizures. MEK inhibitors are increasingly being used to treat LGG, but their effect on associated neurologic symptoms has not been established. Results Here, we report a patient...

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Bibliographic Details
Published in:Child's nervous system 2022-11, Vol.38 (11), p.2245-2249
Main Authors: Cantor, Evan, Meyer, Ashley, Morris, Stephanie M., Weisenberg, Judith L. Z., Brossier, Nicole M.
Format: Article
Language:English
Subjects:
Case Report
Medicine
Medicine & Public Health
Neurosciences
Neurosurgery
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Summary:Background Low-grade gliomas (LGGs) occurring in children can result in many different neurologic complications, including seizures. MEK inhibitors are increasingly being used to treat LGG, but their effect on associated neurologic symptoms has not been established. Results Here, we report a patient with neurofibromatosis type 1 (NF1), medically refractory epilepsy (MRE), and an extensive optic pathway glioma (OPG) who developed dose-dependent seizure control while being treated with selumetinib. Seizure frequency rebounded after dose reduction for cardiac toxicity, then improved, and finally ceased after restarting full dosing, allowing confidence in the cause of improvement. Conclusion Selumetinib may have promise in epilepsy management in other children with NF1 or LGG.
ISSN:0256-7040
1433-0350
DOI:10.1007/s00381-022-05571-y