The Beauty and Complexity of Blood Vessel Patterning

This review highlights new concepts in vascular patterning in the last 10 years, with emphasis on its beauty and complexity. Endothelial cell signaling pathways that respond to molecular or mechanical signals are described, and examples of vascular patterning that use these pathways in brain, skin,...

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Bibliographic Details
Published in:Cold Spring Harbor perspectives in medicine 2022-11, Vol.12 (11), p.a041167
Main Authors: Bautch, Victoria L, Mukouyama, Yoh-Suke
Format: Article
Language:English
Subjects:
Arteriovenous Malformations - metabolism
Arteriovenous Malformations - pathology
Brain - metabolism
Humans
Signal Transduction
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Summary:This review highlights new concepts in vascular patterning in the last 10 years, with emphasis on its beauty and complexity. Endothelial cell signaling pathways that respond to molecular or mechanical signals are described, and examples of vascular patterning that use these pathways in brain, skin, heart, and kidney are highlighted. The pathological consequences of patterning loss are discussed in the context of arteriovenous malformations (AVMs), and prospects for the next 10 years presented.
ISSN:2157-1422
2472-5412
DOI:10.1101/cshperspect.a041167