Integrated network pharmacology approach shows a potential role of Ginseng catechins and ginsenosides in modulating protein aggregation in Amyotrophic Lateral Sclerosis

Amyotrophic lateral Sclerosis is an incurable, progressive neurodegenerative motor neuron disease. The disease is characterized by protein aggregates. The symptoms include weakness, denervation of muscles, atrophy and progressive paralysis of bulbar and respiratory muscles and dysphagia. Various sec...

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Bibliographic Details
Published in:3 Biotech 2022-12, Vol.12 (12), p.333-333, Article 333
Main Authors: Swaroop, R. Sai, Pradhan, Sai Sanwid, Darshan, V. M. Datta, Phalguna, Kanikaram Sai, Sivaramakrishnan, Venketesh
Format: Article
Language:English
Subjects:
Agglomeration
Agriculture
AKT protein
Amyotrophic lateral sclerosis
Atrophy
Bioinformatics
Biomaterials
Biotechnology
Cancer Research
Catechin
Chemical compounds
Chemistry
Chemistry and Materials Science
Denervation
Dysphagia
Ginseng
Ginsenosides
Metabolites
Motor neuron diseases
Muscles
Neurodegenerative diseases
Original
Original Article
Paralysis
Pharmacology
Protein interaction
Proteins
Secondary metabolites
Signs and symptoms
Stem Cells
Transcriptomics
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Summary:Amyotrophic lateral Sclerosis is an incurable, progressive neurodegenerative motor neuron disease. The disease is characterized by protein aggregates. The symptoms include weakness, denervation of muscles, atrophy and progressive paralysis of bulbar and respiratory muscles and dysphagia. Various secondary metabolites are evaluated for their ability to improve symptoms in ALS. Ginseng has been traditionally used for treating several neurodegenerative diseases. Several studies using model systems have shown a potential role of Ginseng catechins and Ginsenosides in clearing protein aggregation associated with ALS. We focus on Network pharmacology approach to understand the effect of Ginseng catechins or ginsenosides on protein aggregation associated with ALS. A catechin/ginsenoside-protein interaction network was generated and the pathways obtained were compared with those obtained from transcriptomic datasets of ALS from GEO database. Knock out of MAPK14, AKT and GSK from Catechin and BACE 1 from ginsenoside modulated pathways inhibited protein aggregation. Catechins and ginsenosides have potential as therapeutic agents in the management of ALS.
ISSN:2190-572X
2190-5738
DOI:10.1007/s13205-022-03401-1