Memory improvement in senile rats after prebiotic and probiotic supplementation is not induced by GLP‐1

Introduction The mechanism underlying the memory improvement induced by prebiotic and probiotic supplementation remains unclear. Glucagon‐like peptide type 1 (GLP‐1) could play an important role since it is induced by prebiotics and enhances memory and learning. Aims We correlated the levels of GLP‐...

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Published in:CNS neuroscience & therapeutics 2022-12, Vol.28 (12), p.1986-1992
Main Authors: Servín‐Casas, Gabriela Andrea, Romo‐Araiza, Alejandra, Gutierrez‐Salmean, Gabriela, Martinez‐Solis, Enrique, Ibarra‐García, Andrea Paola, Cruz‐Martinez, Yolanda, Rodriguez‐Barrera, Roxana, García, Elisa, Incontri‐Abraham, Diego, Ibarra, Antonio
Format: Article
Language:English
Subjects:
Animal cognition
Animal memory
Animals
Dietary Supplements
Glucagon
Glucagon-Like Peptide 1
Homogenization
Inulin
Laboratory animals
Latency
Microbiota
microbiota‐gut‐brain axis
Original
Prebiotics
Probiotics
Rats
Sample size
Small intestine
Spatial memory
Supplements
symbiotic
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Summary:Introduction The mechanism underlying the memory improvement induced by prebiotic and probiotic supplementation remains unclear. Glucagon‐like peptide type 1 (GLP‐1) could play an important role since it is induced by prebiotics and enhances memory and learning. Aims We correlated the levels of GLP‐1 with spatial memory in senile animals to determine its role in memory improvement after prebiotic and probiotic supplementation. Methods Senile rats were randomly assigned to four groups: (1) water (control); (2) Enterococcus faecium (probiotic); (3) agave inulin (prebiotic); and (4) E. faecium + agave inulin (symbiotic). Each supplement was administered by an orogastric cannula for 5 weeks. In the fifth week, spatial memory was assessed using the Morris Water Maze test (MWM). We extracted the hippocampus, intestine, and serum. GLP‐1 levels were quantified by enzyme‐linked immunosorbent assay. Results A significant decrease in escape latency time in the MWM was observed in all groups treated with supplements. The symbiotic group achieved the highest reduction (15.13 s ± 6.40) (p  0.05). Conclusion Prebiotic and probiotic supplementation improved spatial memory in senile animals. However, this beneficial effect did not correlate with GLP‐1 levels. GLP‐1 levels do not correlate with spatial memory in symbiotic‐treated rats. No significant correlation was observed between spatial memory and GLP‐1 concentrations in serum, ileum, and hippocampus.
ISSN:1755-5930
1755-5949
DOI:10.1111/cns.13951