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Temporal trends in the prevalence and incidence of depression and the interplay of comorbidities in patients with young- and usual-onset type 2 diabetes from the USA and the UK
Aims/hypothesis We aimed to investigate the prevalence and incidence of depression, and the interplay of cardiometabolic comorbidities, in the differentiation of depression risk between young-onset diabetes (diagnosis at age
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| Published in: | Diabetologia 2022-12, Vol.65 (12), p.2066-2077 |
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| container_end_page | 2077 |
| container_issue | 12 |
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| container_title | Diabetologia |
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| creator | Dibato, John Montvida, Olga Ling, Joanna Koye, Digsu Polonsky, William H. Paul, Sanjoy K. |
| description | Aims/hypothesis
We aimed to investigate the prevalence and incidence of depression, and the interplay of cardiometabolic comorbidities, in the differentiation of depression risk between young-onset diabetes (diagnosis at age |
| doi_str_mv | 10.1007/s00125-022-05764-9 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_9630215</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2731286956</sourcerecordid><originalsourceid>FETCH-LOGICAL-c474t-b4b336889531428d9a971f9b9e5e357b893a7d92e8f0104b410586c6d4e462803</originalsourceid><addsrcrecordid>eNp9Ustu1DAUtRCIDoUfYIEssWET8CtOvEGqKl6iEgs6EjvLSW5mXCV2sJ1W81d8Ik6mDI8F3tjX59xzHzoIPafkNSWkehMJoawsCGMFKSspCvUAbajgORSsfog2C17QWn47Q09ivCGE8FLIx-iMS1IqwugG_biGcfLBDDgFcF3E1uG0BzwFuDUDuBawcV3-bW23Rr7HHWQ0Ruvdii106xKEaTCHBW_96ENjO5ssrIKTyS-XIr6zaY8Pfna7Yk2d42yGwrsICafDBJjhzpoGUs7rgx9X7e3Xi1Od7een6FFvhgjP7u9ztH3_7vryY3H15cOny4urohWVSEUjGs5lXauS07yMThlV0V41CkrgZdXUipuqUwzqnlAiGkFJWctWdgKEZDXh5-jtUXeamxG6Nveft6SnYEcTDtobq_9GnN3rnb_VSvK82TILvLoXCP77DDHp0cYWhsE48HPUrCJK0XwW6st_qDd-Di6Pl1mcslqqUmYWO7La4GMM0J-aoUQvhtBHQ-hsCL0aQquc9OLPMU4pvxyQCfxIiBlyOwi_a_9H9icDjMLi</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2731286956</pqid></control><display><type>article</type><title>Temporal trends in the prevalence and incidence of depression and the interplay of comorbidities in patients with young- and usual-onset type 2 diabetes from the USA and the UK</title><source>Springer Nature</source><creator>Dibato, John ; Montvida, Olga ; Ling, Joanna ; Koye, Digsu ; Polonsky, William H. ; Paul, Sanjoy K.</creator><creatorcontrib>Dibato, John ; Montvida, Olga ; Ling, Joanna ; Koye, Digsu ; Polonsky, William H. ; Paul, Sanjoy K.</creatorcontrib><description>Aims/hypothesis
We aimed to investigate the prevalence and incidence of depression, and the interplay of cardiometabolic comorbidities, in the differentiation of depression risk between young-onset diabetes (diagnosis at age <40 years) and usual-onset diabetes (diagnosis at age ≥40 years).
Methods
Using electronic medical records from the UK and USA, retrospective cohorts of adults with incident type 2 diabetes diagnosed between 2006 and 2017 were examined. Trends in the prevalence and incidence of depression, and risk of developing depression, in participants with young-onset type 2 diabetes compared with usual-onset type 2 diabetes were assessed separately by sex and comorbidity status.
Results
In total 230,932/1,143,122 people with type 2 diabetes from the UK/USA (mean age 58/60 years, proportion of men 57%/46%) were examined. The prevalence of depression in the UK/USA increased from 29% (95% CI 28, 30)/22% (95% CI 21, 23) in 2006 to 43% (95% CI 42, 44)/29% (95% CI 28, 29) in 2017, with the prevalence being similar across all age groups. A similar increasing trend was observed for incidence rates. In the UK, compared with people aged ≥50 years with or without comorbidity, 18–39-year-old men and women had 23–57% and 20–55% significantly higher risks of depression, respectively. In the USA, compared with those aged ≥60 years with or without comorbidity, 18–39-year-old men and women had 5–17% and 8–37% significantly higher risks of depression, respectively.
Conclusions/interpretation
Depression risk has been increasing in people with incident type 2 diabetes in the UK and USA, particularly among those with young-onset type 2 diabetes, irrespective of other comorbidities. This suggests that proactive mental health assessment from the time of type 2 diabetes diagnosis in primary care is essential for effective clinical management of people with type 2 diabetes.
Graphical abstract</description><identifier>ISSN: 0012-186X</identifier><identifier>EISSN: 1432-0428</identifier><identifier>DOI: 10.1007/s00125-022-05764-9</identifier><identifier>PMID: 36059021</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Adolescent ; Adult ; Age ; Comorbidity ; Depression - epidemiology ; Diabetes ; Diabetes mellitus (non-insulin dependent) ; Diabetes Mellitus, Type 2 - epidemiology ; Diagnosis ; Electronic medical records ; Female ; Human Physiology ; Humans ; Incidence ; Internal Medicine ; Male ; Medicine ; Medicine & Public Health ; Mental depression ; Metabolic Diseases ; Middle Aged ; Prevalence ; Primary care ; Retrospective Studies ; Trends ; United Kingdom - epidemiology ; Young Adult</subject><ispartof>Diabetologia, 2022-12, Vol.65 (12), p.2066-2077</ispartof><rights>The Author(s) 2022</rights><rights>2022. The Author(s).</rights><rights>The Author(s) 2022. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c474t-b4b336889531428d9a971f9b9e5e357b893a7d92e8f0104b410586c6d4e462803</citedby><cites>FETCH-LOGICAL-c474t-b4b336889531428d9a971f9b9e5e357b893a7d92e8f0104b410586c6d4e462803</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,780,784,885,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36059021$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Dibato, John</creatorcontrib><creatorcontrib>Montvida, Olga</creatorcontrib><creatorcontrib>Ling, Joanna</creatorcontrib><creatorcontrib>Koye, Digsu</creatorcontrib><creatorcontrib>Polonsky, William H.</creatorcontrib><creatorcontrib>Paul, Sanjoy K.</creatorcontrib><title>Temporal trends in the prevalence and incidence of depression and the interplay of comorbidities in patients with young- and usual-onset type 2 diabetes from the USA and the UK</title><title>Diabetologia</title><addtitle>Diabetologia</addtitle><addtitle>Diabetologia</addtitle><description>Aims/hypothesis
We aimed to investigate the prevalence and incidence of depression, and the interplay of cardiometabolic comorbidities, in the differentiation of depression risk between young-onset diabetes (diagnosis at age <40 years) and usual-onset diabetes (diagnosis at age ≥40 years).
Methods
Using electronic medical records from the UK and USA, retrospective cohorts of adults with incident type 2 diabetes diagnosed between 2006 and 2017 were examined. Trends in the prevalence and incidence of depression, and risk of developing depression, in participants with young-onset type 2 diabetes compared with usual-onset type 2 diabetes were assessed separately by sex and comorbidity status.
Results
In total 230,932/1,143,122 people with type 2 diabetes from the UK/USA (mean age 58/60 years, proportion of men 57%/46%) were examined. The prevalence of depression in the UK/USA increased from 29% (95% CI 28, 30)/22% (95% CI 21, 23) in 2006 to 43% (95% CI 42, 44)/29% (95% CI 28, 29) in 2017, with the prevalence being similar across all age groups. A similar increasing trend was observed for incidence rates. In the UK, compared with people aged ≥50 years with or without comorbidity, 18–39-year-old men and women had 23–57% and 20–55% significantly higher risks of depression, respectively. In the USA, compared with those aged ≥60 years with or without comorbidity, 18–39-year-old men and women had 5–17% and 8–37% significantly higher risks of depression, respectively.
Conclusions/interpretation
Depression risk has been increasing in people with incident type 2 diabetes in the UK and USA, particularly among those with young-onset type 2 diabetes, irrespective of other comorbidities. This suggests that proactive mental health assessment from the time of type 2 diabetes diagnosis in primary care is essential for effective clinical management of people with type 2 diabetes.
Graphical abstract</description><subject>Adolescent</subject><subject>Adult</subject><subject>Age</subject><subject>Comorbidity</subject><subject>Depression - epidemiology</subject><subject>Diabetes</subject><subject>Diabetes mellitus (non-insulin dependent)</subject><subject>Diabetes Mellitus, Type 2 - epidemiology</subject><subject>Diagnosis</subject><subject>Electronic medical records</subject><subject>Female</subject><subject>Human Physiology</subject><subject>Humans</subject><subject>Incidence</subject><subject>Internal Medicine</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Mental depression</subject><subject>Metabolic Diseases</subject><subject>Middle Aged</subject><subject>Prevalence</subject><subject>Primary care</subject><subject>Retrospective Studies</subject><subject>Trends</subject><subject>United Kingdom - epidemiology</subject><subject>Young Adult</subject><issn>0012-186X</issn><issn>1432-0428</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><recordid>eNp9Ustu1DAUtRCIDoUfYIEssWET8CtOvEGqKl6iEgs6EjvLSW5mXCV2sJ1W81d8Ik6mDI8F3tjX59xzHzoIPafkNSWkehMJoawsCGMFKSspCvUAbajgORSsfog2C17QWn47Q09ivCGE8FLIx-iMS1IqwugG_biGcfLBDDgFcF3E1uG0BzwFuDUDuBawcV3-bW23Rr7HHWQ0Ruvdii106xKEaTCHBW_96ENjO5ssrIKTyS-XIr6zaY8Pfna7Yk2d42yGwrsICafDBJjhzpoGUs7rgx9X7e3Xi1Od7een6FFvhgjP7u9ztH3_7vryY3H15cOny4urohWVSEUjGs5lXauS07yMThlV0V41CkrgZdXUipuqUwzqnlAiGkFJWctWdgKEZDXh5-jtUXeamxG6Nveft6SnYEcTDtobq_9GnN3rnb_VSvK82TILvLoXCP77DDHp0cYWhsE48HPUrCJK0XwW6st_qDd-Di6Pl1mcslqqUmYWO7La4GMM0J-aoUQvhtBHQ-hsCL0aQquc9OLPMU4pvxyQCfxIiBlyOwi_a_9H9icDjMLi</recordid><startdate>20221201</startdate><enddate>20221201</enddate><creator>Dibato, John</creator><creator>Montvida, Olga</creator><creator>Ling, Joanna</creator><creator>Koye, Digsu</creator><creator>Polonsky, William H.</creator><creator>Paul, Sanjoy K.</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><scope>C6C</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7T5</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>H94</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20221201</creationdate><title>Temporal trends in the prevalence and incidence of depression and the interplay of comorbidities in patients with young- and usual-onset type 2 diabetes from the USA and the UK</title><author>Dibato, John ; Montvida, Olga ; Ling, Joanna ; Koye, Digsu ; Polonsky, William H. ; Paul, Sanjoy K.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c474t-b4b336889531428d9a971f9b9e5e357b893a7d92e8f0104b410586c6d4e462803</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Age</topic><topic>Comorbidity</topic><topic>Depression - epidemiology</topic><topic>Diabetes</topic><topic>Diabetes mellitus (non-insulin dependent)</topic><topic>Diabetes Mellitus, Type 2 - epidemiology</topic><topic>Diagnosis</topic><topic>Electronic medical records</topic><topic>Female</topic><topic>Human Physiology</topic><topic>Humans</topic><topic>Incidence</topic><topic>Internal Medicine</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Mental depression</topic><topic>Metabolic Diseases</topic><topic>Middle Aged</topic><topic>Prevalence</topic><topic>Primary care</topic><topic>Retrospective Studies</topic><topic>Trends</topic><topic>United Kingdom - epidemiology</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Dibato, John</creatorcontrib><creatorcontrib>Montvida, Olga</creatorcontrib><creatorcontrib>Ling, Joanna</creatorcontrib><creatorcontrib>Koye, Digsu</creatorcontrib><creatorcontrib>Polonsky, William H.</creatorcontrib><creatorcontrib>Paul, Sanjoy K.</creatorcontrib><collection>SpringerOpen(OpenAccess)</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Immunology Abstracts</collection><collection>ProQuest - Health & Medical Complete保健、医学与药学数据库</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Diabetologia</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Dibato, John</au><au>Montvida, Olga</au><au>Ling, Joanna</au><au>Koye, Digsu</au><au>Polonsky, William H.</au><au>Paul, Sanjoy K.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Temporal trends in the prevalence and incidence of depression and the interplay of comorbidities in patients with young- and usual-onset type 2 diabetes from the USA and the UK</atitle><jtitle>Diabetologia</jtitle><stitle>Diabetologia</stitle><addtitle>Diabetologia</addtitle><date>2022-12-01</date><risdate>2022</risdate><volume>65</volume><issue>12</issue><spage>2066</spage><epage>2077</epage><pages>2066-2077</pages><issn>0012-186X</issn><eissn>1432-0428</eissn><abstract>Aims/hypothesis
We aimed to investigate the prevalence and incidence of depression, and the interplay of cardiometabolic comorbidities, in the differentiation of depression risk between young-onset diabetes (diagnosis at age <40 years) and usual-onset diabetes (diagnosis at age ≥40 years).
Methods
Using electronic medical records from the UK and USA, retrospective cohorts of adults with incident type 2 diabetes diagnosed between 2006 and 2017 were examined. Trends in the prevalence and incidence of depression, and risk of developing depression, in participants with young-onset type 2 diabetes compared with usual-onset type 2 diabetes were assessed separately by sex and comorbidity status.
Results
In total 230,932/1,143,122 people with type 2 diabetes from the UK/USA (mean age 58/60 years, proportion of men 57%/46%) were examined. The prevalence of depression in the UK/USA increased from 29% (95% CI 28, 30)/22% (95% CI 21, 23) in 2006 to 43% (95% CI 42, 44)/29% (95% CI 28, 29) in 2017, with the prevalence being similar across all age groups. A similar increasing trend was observed for incidence rates. In the UK, compared with people aged ≥50 years with or without comorbidity, 18–39-year-old men and women had 23–57% and 20–55% significantly higher risks of depression, respectively. In the USA, compared with those aged ≥60 years with or without comorbidity, 18–39-year-old men and women had 5–17% and 8–37% significantly higher risks of depression, respectively.
Conclusions/interpretation
Depression risk has been increasing in people with incident type 2 diabetes in the UK and USA, particularly among those with young-onset type 2 diabetes, irrespective of other comorbidities. This suggests that proactive mental health assessment from the time of type 2 diabetes diagnosis in primary care is essential for effective clinical management of people with type 2 diabetes.
Graphical abstract</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>36059021</pmid><doi>10.1007/s00125-022-05764-9</doi><tpages>12</tpages><oa>free_for_read</oa></addata></record> |
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| issn | 0012-186X 1432-0428 |
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| source | Springer Nature |
| subjects | Adolescent Adult Age Comorbidity Depression - epidemiology Diabetes Diabetes mellitus (non-insulin dependent) Diabetes Mellitus, Type 2 - epidemiology Diagnosis Electronic medical records Female Human Physiology Humans Incidence Internal Medicine Male Medicine Medicine & Public Health Mental depression Metabolic Diseases Middle Aged Prevalence Primary care Retrospective Studies Trends United Kingdom - epidemiology Young Adult |
| title | Temporal trends in the prevalence and incidence of depression and the interplay of comorbidities in patients with young- and usual-onset type 2 diabetes from the USA and the UK |
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