Immunosuppression Exposure and Risk of Infection-Related Acute Care Events in Patients With Glomerular Disease: An Observational Cohort Study

Infections cause morbidity and mortality in patients with glomerular disease. The relative contributions from immunosuppression exposure and glomerular disease activity to infection risk are not well characterized. To address this unmet need, we characterized the relationship between time-varying co...

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Bibliographic Details
Published in:Kidney medicine 2022-11, Vol.4 (11), p.100553-100553, Article 100553
Main Authors: Glenn, Dorey A., Zee, Jarcy, Mansfield, Sarah, O’Shaughnessy, Michelle M., Bomback, Andrew S., Gibson, Keisha, Greenbaum, Larry A., Mariani, Laura, Falk, Ronald, Hogan, Susan, Mottl, Amy, Denburg, Michelle R.
Format: Article
Language:English
Subjects:
Corticosteroids
glomerular disease
glomerulonephritis
hospitalization
immunosuppression
infection
Original Research
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Summary:Infections cause morbidity and mortality in patients with glomerular disease. The relative contributions from immunosuppression exposure and glomerular disease activity to infection risk are not well characterized. To address this unmet need, we characterized the relationship between time-varying combinations of immunosuppressant exposure and infection-related acute care events while controlling for disease activity, among individuals with glomerular disease. Prospective, multicenter, observational cohort study. Adults and children with biopsy-proven minimal change disease, focal segmental glomerulosclerosis, membranous nephropathy, or immunoglobulin A nephropathy/vasculitis were enrolled at 71 clinical sites in North America and Europe. A total of 2,388 Cure Glomerulonephropathy Network participants (36% aged
ISSN:2590-0595
2590-0595
DOI:10.1016/j.xkme.2022.100553