Endoscopic Findings and Treatment of Gastric Neoplasms in Familial Adenomatous Polyposis

PURPOSEGastric neoplasia is a common manifestation of familial adenomatous polyposis (FAP). This study aimed to elucidate the clinical characteristics, endoscopic features including fundic gland polyposis (FGPsis), and treatment outcomes of gastric neoplasms (GNs) in patients with FAP. MATERIALS AND...

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Published in:Journal of gastric cancer 2022-10, Vol.22 (4), p.381-394
Main Authors: Sato, Chihiro, Takahashi, Kazuya, Sato, Hiroki, Naruse, Takumi, Nakajima, Nao, Takatsuna, Masafumi, Mizuno, Ken-ichi, Hashimoto, Satoru, Takeuchi, Manabu, Yokoyama, Junji, Kobayashi, Masaaki, Terai, Shuji
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Language:English
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Summary:PURPOSEGastric neoplasia is a common manifestation of familial adenomatous polyposis (FAP). This study aimed to elucidate the clinical characteristics, endoscopic features including fundic gland polyposis (FGPsis), and treatment outcomes of gastric neoplasms (GNs) in patients with FAP. MATERIALS AND METHODSA total of 35 patients diagnosed with FAP, including nine patients from four pedigrees who underwent esophagogastroduodenoscopy (EGD), were investigated regarding patient characteristics, GN morphology, and treatment outcomes. RESULTSTwenty-one patients (60.0%) had 38 GNs; 33 (86.8%) and 5 (13.2%) were histologically diagnosed with adenocarcinoma and adenoma, respectively. There were no specific patient characteristics related to GNs. Nodule-type GNs were more prevalent in patients with FGP than without (52.2% vs. 0.0%, P=0.002) in the upper body of the stomach. Conversely, depressed-type GNs were fewer in patients with FGPsis than in those without (13.0% vs. 73.3%, P
ISSN:2093-582X
2093-5641
DOI:10.5230/jgc.2022.22.e30