Omicron BA.2.75 variant is efficiently neutralised following BA.1 and BA.5 breakthrough infection in vaccinated individuals, Israel, June to September 2022

We evaluated neutralising antibody titres against wild type (WT) SARS-CoV-2 and four Omicron variants (BA.1, BA.2, BA.5 and BA.2.75) in fully vaccinated (three doses of Comirnaty vaccine) healthcare workers (HCW) in Israel who had breakthrough BA.1/BA5 infections. Omicron breakthrough infections in...

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Published in:Euro surveillance : bulletin européen sur les maladies transmissibles 2022-11, Vol.27 (44), p.1
Main Authors: Atari, Nofar, Kliker, Limor, Zuckerman, Neta, Elkader, Bayan Abd, Weiss-Ottolenghi, Yael, Mendelson, Ella, Kreiss, Yitshak, Regev-Yochay, Gili, Mandelboim, Michal
Format: Article
Language:English
Subjects:
Antibodies
COVID-19
COVID-19 vaccines
Medical personnel
Rapid Communication
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Summary:We evaluated neutralising antibody titres against wild type (WT) SARS-CoV-2 and four Omicron variants (BA.1, BA.2, BA.5 and BA.2.75) in fully vaccinated (three doses of Comirnaty vaccine) healthcare workers (HCW) in Israel who had breakthrough BA.1/BA5 infections. Omicron breakthrough infections in vaccinated individuals resulted in increased neutralising antibodies against the WT and Omicron variants compared with vaccinated uninfected HCW. HCW who recovered from BA.1 or BA.5 infections showed similar neutralising antibodies levels against BA.2.75.
ISSN:1560-7917
1025-496X
1560-7917
DOI:10.2807/1560-7917.ES.2022.27.44.2200785