Adverse Obstetric Outcomes in Pregnant Women Using Natalizumab for the Treatment of Multiple Sclerosis: A Systematic Review

Multiple sclerosis is a common disease in women of childbearing age, characterized by demyelination of the central nervous system. Among the different treatment options available, disease-modifying therapies (DMTs) are the most efficacious, and natalizumab (NAT) is an injectable DMT best for relapsi...

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Published in:Curēus (Palo Alto, CA) CA), 2022-10, Vol.14 (10), p.e29952-e29952
Main Authors: Ramesh, Vaiishnavi, Opara, Collins O, Khan, Farhana Yaqoob, Kabiraj, Gargi, Kauser, Humaira, Palakeel, Jaimee J, Ali, Mazin, Chaduvula, Phani, Chhabra, Sanika, Lamsal Lamichhane, Smriti, Khan, Safeera
Format: Article
Language:English
Subjects:
Anemia
Cohort analysis
Congenital diseases
Hematology
Internal Medicine
Medical Subject Headings-MeSH
Meta-analysis
Miscarriage
Monoclonal antibodies
Mothers
Multiple sclerosis
Nervous system
Neurology
Newborn babies
Observational studies
Obstetrics
Obstetrics/Gynecology
Patients
Pregnancy
Systematic review
Thrombocytopenia
Womens health
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Summary:Multiple sclerosis is a common disease in women of childbearing age, characterized by demyelination of the central nervous system. Among the different treatment options available, disease-modifying therapies (DMTs) are the most efficacious, and natalizumab (NAT) is an injectable DMT best for relapsing-remitting multiple sclerosis. However, it comes under pregnancy category C drug classification. This systematic review aims to analyze the adverse outcomes of using NAT during pregnancy.PubMed/Medline, PubMed Central (PMC), ScienceDirect, and Google Scholar were the databases used to search for articles. Appropriate keywords and Medical Subject Headings (MeSH) strategy were used to identify relevant articles. Articles were then screened using inclusion/exclusion criteria followed by the title and abstract screening. The Joanna Briggs Institute (JBI) quality appraisal tools were used for quality check, and nine articles were finalized for review.NAT suspension during pregnancy is shown to have a high risk of disease relapse. Despite the risk of mild hematological abnormalities in the newborn and the risk of spontaneous abortions at the same rate as that of the general population, NAT use can be considered safe in pregnancy. These adverse outcomes can be minimized by strict monitoring of patients. Studies of better quality with larger sample sizes are needed for further investigation.
ISSN:2168-8184
2168-8184
DOI:10.7759/cureus.29952