The identification of TCF1+ progenitor exhausted T cells in THRLBCL may predict a better response to PD-1/PD-L1 blockade

T-cell/histiocyte-rich large B-cell lymphoma (THRLBCL) is a rare and aggressive variant of diffuse large B-cell lymphoma (DLBCL) that usually affects young to middle-aged patients, with disseminated disease at presentation. The tumor microenvironment (TME) plays a key role in THRLBCL due to its pecu...

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Published in:Blood advances 2022-08, Vol.6 (15), p.4634-4644
Main Authors: Tabanelli, Valentina, Melle, Federica, Motta, Giovanna, Mazzara, Saveria, Fabbri, Marco, Agostinelli, Claudio, Calleri, Angelica, Del Corvo, Marcello, Fiori, Stefano, Lorenzini, Daniele, Cesano, Alessandra, Chiappella, Annalisa, Vitolo, Umberto, Derenzini, Enrico, Griffin, Gabriel K., Rodig, Scott J., Vanazzi, Anna, Sabattini, Elena, Tarella, Corrado, Sapienza, Maria Rosaria, Pileri, Stefano A.
Format: Article
Language:English
Subjects:
Immunobiology and Immunotherapy
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Summary:T-cell/histiocyte-rich large B-cell lymphoma (THRLBCL) is a rare and aggressive variant of diffuse large B-cell lymphoma (DLBCL) that usually affects young to middle-aged patients, with disseminated disease at presentation. The tumor microenvironment (TME) plays a key role in THRLBCL due to its peculiar cellular composition (
ISSN:2473-9529
2473-9537
DOI:10.1182/bloodadvances.2022007046