COVID-19-associated secondary sclerosing cholangitis – A case series of 4 patients

We report a case series of four patients diagnosed with COVID-19-associated secondary sclerosing cholangitis (SSC), a recently described rare late complication of severe COVID-19. Following prolonged stays in the intensive care unit, these patients developed marked sustained cholestasis and jaundice...

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Bibliographic Details
Published in:Clinics and research in hepatology and gastroenterology 2022-12, Vol.46 (10), p.102048, Article 102048
Main Authors: Ferreira, Filipa Bordalo, Mourato, Margarida, Bragança, Sofia, Paulo, Joana Batista, Sismeiro, Rita, Pereira, André, Mónica, Ana Nassauer, Lourenço, Luís Carvalho, Cardoso, Mariana
Format: Article
Language:English
Subjects:
Bile Ducts, Intrahepatic
Case series
Cholangiography
Cholangiopathy
Cholangitis, Sclerosing - complications
Cholestasis - complications
COVID-19
COVID-19 - complications
Humans
Secondary sclerosing cholangitis
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Summary:We report a case series of four patients diagnosed with COVID-19-associated secondary sclerosing cholangitis (SSC), a recently described rare late complication of severe COVID-19. Following prolonged stays in the intensive care unit, these patients developed marked sustained cholestasis and jaundice despite clinical improvement. Cholangiography showed beaded appearance of intra-hepatic bile ducts and bile casts were removed in one patient. None of the patients reached normalization of liver enzymes and at least one progressed to liver cirrhosis (follow-up time of 11 to 16 months). COVID-19-associated SSC has a dismal prognosis with rapid progression to advanced chronic liver disease.
ISSN:2210-7401
2210-741X
DOI:10.1016/j.clinre.2022.102048