Endocrine disrupting chemicals: effects on pituitary, thyroid and adrenal glands

Background In recent years, scientific research has increasingly focused on Endocrine Disrupting Chemicals (EDCs) and demonstrated their relevant role in the functional impairment of endocrine glands. This induced regulatory authorities to ban some of these compounds and to carefully investigate oth...

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Bibliographic Details
Published in:Endocrine 2022-12, Vol.78 (3), p.395-405
Main Authors: Egalini, Filippo, Marinelli, Lorenzo, Rossi, Mattia, Motta, Giovanna, Prencipe, Nunzia, Rossetto Giaccherino, Ruth, Pagano, Loredana, Grottoli, Silvia, Giordano, Roberta
Format: Article
Language:English
Subjects:
Adrenal glands
Diabetes
Endocrine disorders
Endocrine disruptors
Endocrine glands
Endocrinology
Humanities and Social Sciences
Internal Medicine
Long-term effects
Medicine
Medicine & Public Health
multidisciplinary
Pituitary
Review
Science
Thyroid
Thyroid gland
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Summary:Background In recent years, scientific research has increasingly focused on Endocrine Disrupting Chemicals (EDCs) and demonstrated their relevant role in the functional impairment of endocrine glands. This induced regulatory authorities to ban some of these compounds and to carefully investigate others in order to prevent EDCs-related conditions. As a result, we witnessed a growing awareness and interest on this topic. Aims This paper aims to summarize current evidence regarding the detrimental effects of EDCs on pivotal endocrine glands like pituitary, thyroid and adrenal ones. Particularly, we directed our attention on the known and the hypothesized mechanisms of endocrine dysfunction brought by EDCs. We also gave a glimpse on recent findings from pioneering studies that could in the future shed a light on the pathophysiology of well-known, but poorly understood, endocrine diseases like hormone-producing adenomas. Conclusions Although intriguing, studies on endocrine dysfunctions brought by EDCs are challenging, in particular when investigating long-term effects of EDCs on humans. However, undoubtedly, it represents a new intriguing field of science research.
ISSN:1559-0100
1355-008X
1559-0100
DOI:10.1007/s12020-022-03076-x