Transurethral Renal Pelvic Denervation: A Feasibility Trial in Patients with Uncontrolled Hypertension

BACKGROUNDEndovascular renal denervation reduces blood pressure (BP). We explored an alternative approach to renal denervation using radiofrequency energy delivered across the renal pelvis utilizing the natural orifice of the urethra and the ureters. METHODSThis open-label, single-arm feasibility st...

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Published in:Hypertension (Dallas, Tex. 1979) Tex. 1979), 2022-12, Vol.79 (12), p.2787-2795
Main Authors: Hering, Dagmara, Nikoleishvili, David, Imedadze, Avtandil, Dughashvili, Gvantsa, Klimiashvili, Zurab, Bekaia, Eter, Shengelia, Tamar, Kobalava, Mamuka, Goguadze, Otar, Emukhvari, Tamar, Druker, Vitaly, Sackner-Bernstein, Jonathan, Weber, Michael A.
Format: Article
Language:English
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Summary:BACKGROUNDEndovascular renal denervation reduces blood pressure (BP). We explored an alternative approach to renal denervation using radiofrequency energy delivered across the renal pelvis utilizing the natural orifice of the urethra and the ureters. METHODSThis open-label, single-arm feasibility study enrolled patients with uncontrolled hypertension despite antihypertensive drug therapy. The primary effectiveness endpoint was the change in ambulatory daytime systolic BP (SBP) 2 months following renal pelvic denervation. RESULTSThe 18 patients (mean age 56±12 years) enrolled were taking an average of 2.7 antihypertensive drugs daily. Renal pelvic denervation reduced mean daytime SBP by 19.4 mm Hg (95% CI, -24.9 to -14.0, P
ISSN:0194-911X
1524-4563
DOI:10.1161/HYPERTENSIONAHA.122.20048