Clinical and Histopathological Predictors of Recurrence in Uterine Smooth Muscle Tumor of Uncertain Malignant Potential (STUMP): A Multicenter Retrospective Cohort Study of Tertiary Centers

• Published in: Annals of surgical oncology 2022-12, Vol.29 (13), p.8302-8314
• Main Authors: Borella, Fulvio, Cosma, Stefano, Ferraioli, Domenico, Ray-Coquard, Isabelle, Chopin, Nicolas, Meeus, Pierre, Cockenpot, Vincent, Valabrega, Giorgio, Scotto, Giulia, Turinetto, Margherita, Biglia, Nicoletta, Fuso, Luca, Mariani, Luca, Franchi, Dorella, Vidal Urbinati, Ailyn Mariela, Pino, Ida, Bertschy, Gianluca, Preti, Mario, Benedetto, Chiara, Castellano, Isabella, Cassoni, Paola, Bertero, Luca
• Format: Article
• Language: English
• Subjects: Cancer; Cohort analysis; Fibroids; Gynecologic Oncology; Medical prognosis; Medicine; Medicine & Public Health; Multivariate analysis; Muscular system; Oncology; Patients; Progesterone; Risk factors; Smooth muscle; Surgery; Surgical Oncology; Tumors; Uterus
• ISSN: 1068-9265; 1534-4681
• DOI: 10.1245/s10434-022-12353-y

Background The term uterine smooth muscle tumor of uncertain malignant potential (STUMP) indicates a rare, equivocal entity between benign leiomyomas and leiomyosarcomas. In the present study, we evaluated a comprehensive range of clinical, surgical, and pathological features in a large multicenter series of patients with STUMP to identify risk factors for recurrence. Methods This is a retrospective study performed by collecting consecutive cases diagnosed between January 2000 and December 2020 in five tertiary centers. Associations between STUMP recurrence and clinicopathological characteristics as well as surgical treatment modality were investigated. Results Eighty-seven patients affected by STUMP were considered. Of them, 18 cases (20.7%) recurred: 11 as leiomyosarcoma (LMS) and 7 as STUMP. The mean time to recurrence was 79 months. We found that fragmentation/morcellation, epithelioid features, high mitotic count, Ki-67 value > 20%, progesterone receptor (PR) < 83%, and p16 diffuse expression were associated with higher risk of recurrence and shorter recurrence-free survival (RFS). Furthermore, morcellation/fragmentation and mitotic count remained independent risk factors for recurrence and shorter RFS after multivariate analysis, while the presence of epithelioid features was an independent risk factor for recurrence only. Conclusions Our results suggest that morcellation is associated with risk of recurrence and shorter RFS, thus it should be avoided if a STUMP is suspected preoperatively. Epithelioid features, high proliferation activity, low PR expression, and diffuse p16 expression are also unfavorable prognostic factors, so patients presenting these features should be closely followed up.