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A systematic review and meta-analysis exploring the efficacy of mindfulness-based interventions on quality of life in people with multiple sclerosis
Background Quality of life (QoL) is commonly impaired among people with multiple sclerosis (PwMS). The aim of this study was to evaluate via meta-analysis the efficacy of Mindfulness-based interventions (MBIs) for improving QoL in PwMS. Methods Eligible randomized controlled trials (RCTs) were ident...
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Published in: | Journal of neurology 2023-02, Vol.270 (2), p.726-745 |
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Main Authors: | , , , , , , , , , |
Format: | Article |
Language: | English |
Subjects: | |
Citations: | Items that this one cites Items that cite this one |
Online Access: | Get full text |
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Summary: | Background
Quality of life (QoL) is commonly impaired among people with multiple sclerosis (PwMS). The aim of this study was to evaluate via meta-analysis the efficacy of Mindfulness-based interventions (MBIs) for improving QoL in PwMS.
Methods
Eligible randomized controlled trials (RCTs) were identified via searching six major electronic databases (MEDLINE, EMBASE, CINAHL, Cochrane Central Register of Controlled Trials, AMED, and PsycINFO) in April 2022. The primary outcome was QoL. Study quality was determined using the Cochrane Collaboration risk of bias tool. Meta-analysis using a random effects model was undertaken. Effect sizes are reported as Standardized Mean Difference (SMD). Prospero ID: 139835.
Results
From a total of 1312 individual studies, 14 RCTs were eligible for inclusion in the meta-analysis, total participant
n
= 937. Most studies included PwMS who remained ambulatory. Cognitively impaired PwMS were largely excluded. Comorbidities were inconsistently reported. Most MBIs were delivered face-to face in group format, but five were online. Eight studies (
n
= 8) measured MS-specific QoL. In meta-analysis, overall effect size (SMD) for any QoL measure (
n
= 14) was 0.40 (0.18–0.61),
p
= 0.0003,
I
2
= 52%. SMD for MS-specific QoL measures (
n
= 8) was 0.39 (0.21–0.57),
p
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ISSN: | 0340-5354 1432-1459 |
DOI: | 10.1007/s00415-022-11451-x |