Effects of Different Organ Metastases on the Prognosis of Stage IV Urothelial Carcinoma of the Bladder

Objective. To assess the prognosis of stage IV metastatic urinary bladder urothelial carcinoma (UBUC) at initial diagnosis and determine prognostic factors based on distant organ metastasis. Methods. A retrospective cohort analysis of UBUC was conducted based on the Surveillance, Epidemiology, and E...

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Bibliographic Details
Published in:Journal of oncology 2022-11, Vol.2022, p.1-12
Main Authors: Liu, Liang, Yuan, Haibo, Wang, Qiang, Li, Chuangui
Format: Article
Language:English
Subjects:
Analysis
Bladder cancer
Cancer
Carcinoma
Epidemiology
Histology
Liver
Males
Medical prognosis
Metastasis
Patients
Prognosis
Risk factors
Surgery
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Summary:Objective. To assess the prognosis of stage IV metastatic urinary bladder urothelial carcinoma (UBUC) at initial diagnosis and determine prognostic factors based on distant organ metastasis. Methods. A retrospective cohort analysis of UBUC was conducted based on the Surveillance, Epidemiology, and End Results (SEER) database. Univariate and multivariate Cox regression analyses were used to determine the variables associated with overall survival (OS). Kaplan–Meier curves were used to compare survival curves among different groups. Results. A total of 3103 patients with stage IV UBUC were selected for analysis. The number of distant organ metastatic sites independently predicted the OS. The OS was not different in other metastatic sites when bone metastasis was used as a reference P>0.05. However, the OS was shorter for a single metastatic site P
ISSN:1687-8450
1687-8450
DOI:10.1155/2022/8594022