Loading…
Managing Adult Acute and Acute-on-Chronic Liver Failure in the ICU
Acute liver failure (ALF) is defined as the development of severe liver injury with associated hepatic encephalopathy and synthetic dysfunction in a patient without known cirrhosis or other preexisting liver disease. Definitions of acute-on-chronic liver failure (ACLF) vary, but generally describe a...
Saved in:
| Published in: | JAMA : the journal of the American Medical Association 2021-11, Vol.326 (19), p.1964-1965 |
|---|---|
| Main Authors: | , , |
| Format: | Article |
| Language: | English |
| Subjects: | |
| Citations: | Items that this one cites Items that cite this one |
| Online Access: | Get full text |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| cited_by | cdi_FETCH-LOGICAL-a440t-d0d8fa4e31c244f1324f452eb131f96b8adcd3f86ccf626da0a3d0cd54be0c983 |
|---|---|
| cites | cdi_FETCH-LOGICAL-a440t-d0d8fa4e31c244f1324f452eb131f96b8adcd3f86ccf626da0a3d0cd54be0c983 |
| container_end_page | 1965 |
| container_issue | 19 |
| container_start_page | 1964 |
| container_title | JAMA : the journal of the American Medical Association |
| container_volume | 326 |
| creator | Han, Xuan Davis, Andrew M Parker, William F |
| description | Acute liver failure (ALF) is defined as the development of severe liver injury with associated hepatic encephalopathy and synthetic dysfunction in a patient without known cirrhosis or other preexisting liver disease. Definitions of acute-on-chronic liver failure (ACLF) vary, but generally describe a syndrome marked by acutely decompensated cirrhosis and extrahepatic organ dysfunction. Here, Han et al offer guidelines that seek to address the distinct pathophysiology of ALF and ACLF, focusing on the cardiovascular, endocrine, hematologic, pulmonary, and renal systems. |
| doi_str_mv | 10.1001/jama.2021.12742 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_9648071</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><ama_id>2786260</ama_id><sourcerecordid>2604048730</sourcerecordid><originalsourceid>FETCH-LOGICAL-a440t-d0d8fa4e31c244f1324f452eb131f96b8adcd3f86ccf626da0a3d0cd54be0c983</originalsourceid><addsrcrecordid>eNpdkc9LwzAUx4MoOn-cBQ9S8OKl28uPNulFmMMfg4kXPYc0SbeMLtW0Ffzvba0bai4JvM_7kvc-CJ1jGGMAPFmrjRoTIHiMCWdkD41wQkVMk0zsoxFAJmLOBDtCx3W9hu5gyg_REWVcUJGQEbp9Ul4tnV9GU9OWTTTVbWMj5c3wiisfz1ah8k5HC_dhQ3SvXNkGGzkfNSsbzWevp-igUGVtz37uE_R6f_cye4wXzw_z2XQRK8agiQ0YUShmKdaEsQJTwgqWEJtjiosszYUy2tBCpFoXKUmNAkUNaJOw3ILOBD1BN0PuW5tvrNHWN0GV8i24jQqfslJO_q14t5LL6kNmKRPAcRdw_RMQqvfW1o3cuFrbslTeVm0tSbc14Jym0KFX_9B11QbfjSdJCgyY4LSnJgOlQ1XXwRa7z2CQvR_Z-5G9H_ntp-u4_D3Djt8K6YCLAegbt1XCRbcRoF-w95OA</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2604048730</pqid></control><display><type>article</type><title>Managing Adult Acute and Acute-on-Chronic Liver Failure in the ICU</title><source>AMA Current Titles</source><creator>Han, Xuan ; Davis, Andrew M ; Parker, William F</creator><creatorcontrib>Han, Xuan ; Davis, Andrew M ; Parker, William F</creatorcontrib><description>Acute liver failure (ALF) is defined as the development of severe liver injury with associated hepatic encephalopathy and synthetic dysfunction in a patient without known cirrhosis or other preexisting liver disease. Definitions of acute-on-chronic liver failure (ACLF) vary, but generally describe a syndrome marked by acutely decompensated cirrhosis and extrahepatic organ dysfunction. Here, Han et al offer guidelines that seek to address the distinct pathophysiology of ALF and ACLF, focusing on the cardiovascular, endocrine, hematologic, pulmonary, and renal systems.</description><identifier>ISSN: 0098-7484</identifier><identifier>EISSN: 1538-3598</identifier><identifier>DOI: 10.1001/jama.2021.12742</identifier><identifier>PMID: 34783852</identifier><language>eng</language><publisher>United States: American Medical Association</publisher><subject>Acute Disease ; Acute-On-Chronic Liver Failure - drug therapy ; Acute-On-Chronic Liver Failure - therapy ; Cirrhosis ; Critical Illness - therapy ; Drug overdose ; Failure ; Glycemic Control ; Hepatic encephalopathy ; Humans ; Hydroxyethyl Starch Derivatives - therapeutic use ; Intensive Care Units ; Liver ; Liver cirrhosis ; Liver failure ; Liver Failure, Acute - drug therapy ; Liver Failure, Acute - therapy ; Norepinephrine - therapeutic use ; Practice Guidelines as Topic ; Vasoconstrictor Agents - therapeutic use</subject><ispartof>JAMA : the journal of the American Medical Association, 2021-11, Vol.326 (19), p.1964-1965</ispartof><rights>Copyright American Medical Association Nov 16, 2021</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-a440t-d0d8fa4e31c244f1324f452eb131f96b8adcd3f86ccf626da0a3d0cd54be0c983</citedby><cites>FETCH-LOGICAL-a440t-d0d8fa4e31c244f1324f452eb131f96b8adcd3f86ccf626da0a3d0cd54be0c983</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,776,780,881,27903,27904</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34783852$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Han, Xuan</creatorcontrib><creatorcontrib>Davis, Andrew M</creatorcontrib><creatorcontrib>Parker, William F</creatorcontrib><title>Managing Adult Acute and Acute-on-Chronic Liver Failure in the ICU</title><title>JAMA : the journal of the American Medical Association</title><addtitle>JAMA</addtitle><description>Acute liver failure (ALF) is defined as the development of severe liver injury with associated hepatic encephalopathy and synthetic dysfunction in a patient without known cirrhosis or other preexisting liver disease. Definitions of acute-on-chronic liver failure (ACLF) vary, but generally describe a syndrome marked by acutely decompensated cirrhosis and extrahepatic organ dysfunction. Here, Han et al offer guidelines that seek to address the distinct pathophysiology of ALF and ACLF, focusing on the cardiovascular, endocrine, hematologic, pulmonary, and renal systems.</description><subject>Acute Disease</subject><subject>Acute-On-Chronic Liver Failure - drug therapy</subject><subject>Acute-On-Chronic Liver Failure - therapy</subject><subject>Cirrhosis</subject><subject>Critical Illness - therapy</subject><subject>Drug overdose</subject><subject>Failure</subject><subject>Glycemic Control</subject><subject>Hepatic encephalopathy</subject><subject>Humans</subject><subject>Hydroxyethyl Starch Derivatives - therapeutic use</subject><subject>Intensive Care Units</subject><subject>Liver</subject><subject>Liver cirrhosis</subject><subject>Liver failure</subject><subject>Liver Failure, Acute - drug therapy</subject><subject>Liver Failure, Acute - therapy</subject><subject>Norepinephrine - therapeutic use</subject><subject>Practice Guidelines as Topic</subject><subject>Vasoconstrictor Agents - therapeutic use</subject><issn>0098-7484</issn><issn>1538-3598</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><recordid>eNpdkc9LwzAUx4MoOn-cBQ9S8OKl28uPNulFmMMfg4kXPYc0SbeMLtW0Ffzvba0bai4JvM_7kvc-CJ1jGGMAPFmrjRoTIHiMCWdkD41wQkVMk0zsoxFAJmLOBDtCx3W9hu5gyg_REWVcUJGQEbp9Ul4tnV9GU9OWTTTVbWMj5c3wiisfz1ah8k5HC_dhQ3SvXNkGGzkfNSsbzWevp-igUGVtz37uE_R6f_cye4wXzw_z2XQRK8agiQ0YUShmKdaEsQJTwgqWEJtjiosszYUy2tBCpFoXKUmNAkUNaJOw3ILOBD1BN0PuW5tvrNHWN0GV8i24jQqfslJO_q14t5LL6kNmKRPAcRdw_RMQqvfW1o3cuFrbslTeVm0tSbc14Jym0KFX_9B11QbfjSdJCgyY4LSnJgOlQ1XXwRa7z2CQvR_Z-5G9H_ntp-u4_D3Djt8K6YCLAegbt1XCRbcRoF-w95OA</recordid><startdate>20211116</startdate><enddate>20211116</enddate><creator>Han, Xuan</creator><creator>Davis, Andrew M</creator><creator>Parker, William F</creator><general>American Medical Association</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7QP</scope><scope>7TK</scope><scope>7TS</scope><scope>7U7</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>K9.</scope><scope>M7N</scope><scope>NAPCQ</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20211116</creationdate><title>Managing Adult Acute and Acute-on-Chronic Liver Failure in the ICU</title><author>Han, Xuan ; Davis, Andrew M ; Parker, William F</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a440t-d0d8fa4e31c244f1324f452eb131f96b8adcd3f86ccf626da0a3d0cd54be0c983</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Acute Disease</topic><topic>Acute-On-Chronic Liver Failure - drug therapy</topic><topic>Acute-On-Chronic Liver Failure - therapy</topic><topic>Cirrhosis</topic><topic>Critical Illness - therapy</topic><topic>Drug overdose</topic><topic>Failure</topic><topic>Glycemic Control</topic><topic>Hepatic encephalopathy</topic><topic>Humans</topic><topic>Hydroxyethyl Starch Derivatives - therapeutic use</topic><topic>Intensive Care Units</topic><topic>Liver</topic><topic>Liver cirrhosis</topic><topic>Liver failure</topic><topic>Liver Failure, Acute - drug therapy</topic><topic>Liver Failure, Acute - therapy</topic><topic>Norepinephrine - therapeutic use</topic><topic>Practice Guidelines as Topic</topic><topic>Vasoconstrictor Agents - therapeutic use</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Han, Xuan</creatorcontrib><creatorcontrib>Davis, Andrew M</creatorcontrib><creatorcontrib>Parker, William F</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Physical Education Index</collection><collection>Toxicology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Nursing & Allied Health Premium</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>JAMA : the journal of the American Medical Association</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Han, Xuan</au><au>Davis, Andrew M</au><au>Parker, William F</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Managing Adult Acute and Acute-on-Chronic Liver Failure in the ICU</atitle><jtitle>JAMA : the journal of the American Medical Association</jtitle><addtitle>JAMA</addtitle><date>2021-11-16</date><risdate>2021</risdate><volume>326</volume><issue>19</issue><spage>1964</spage><epage>1965</epage><pages>1964-1965</pages><issn>0098-7484</issn><eissn>1538-3598</eissn><abstract>Acute liver failure (ALF) is defined as the development of severe liver injury with associated hepatic encephalopathy and synthetic dysfunction in a patient without known cirrhosis or other preexisting liver disease. Definitions of acute-on-chronic liver failure (ACLF) vary, but generally describe a syndrome marked by acutely decompensated cirrhosis and extrahepatic organ dysfunction. Here, Han et al offer guidelines that seek to address the distinct pathophysiology of ALF and ACLF, focusing on the cardiovascular, endocrine, hematologic, pulmonary, and renal systems.</abstract><cop>United States</cop><pub>American Medical Association</pub><pmid>34783852</pmid><doi>10.1001/jama.2021.12742</doi><tpages>2</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0098-7484 |
| ispartof | JAMA : the journal of the American Medical Association, 2021-11, Vol.326 (19), p.1964-1965 |
| issn | 0098-7484 1538-3598 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_9648071 |
| source | AMA Current Titles |
| subjects | Acute Disease Acute-On-Chronic Liver Failure - drug therapy Acute-On-Chronic Liver Failure - therapy Cirrhosis Critical Illness - therapy Drug overdose Failure Glycemic Control Hepatic encephalopathy Humans Hydroxyethyl Starch Derivatives - therapeutic use Intensive Care Units Liver Liver cirrhosis Liver failure Liver Failure, Acute - drug therapy Liver Failure, Acute - therapy Norepinephrine - therapeutic use Practice Guidelines as Topic Vasoconstrictor Agents - therapeutic use |
| title | Managing Adult Acute and Acute-on-Chronic Liver Failure in the ICU |
| url | http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-24T23%3A02%3A35IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Managing%20Adult%20Acute%20and%20Acute-on-Chronic%20Liver%20Failure%20in%20the%20ICU&rft.jtitle=JAMA%20:%20the%20journal%20of%20the%20American%20Medical%20Association&rft.au=Han,%20Xuan&rft.date=2021-11-16&rft.volume=326&rft.issue=19&rft.spage=1964&rft.epage=1965&rft.pages=1964-1965&rft.issn=0098-7484&rft.eissn=1538-3598&rft_id=info:doi/10.1001/jama.2021.12742&rft_dat=%3Cproquest_pubme%3E2604048730%3C/proquest_pubme%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-a440t-d0d8fa4e31c244f1324f452eb131f96b8adcd3f86ccf626da0a3d0cd54be0c983%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=2604048730&rft_id=info:pmid/34783852&rfr_iscdi=true |