Gold Nanoparticle-Mediated Gene Therapy

Gold nanoparticles (AuNPs) have gained increasing attention as novel drug-delivery nanostructures for the treatment of cancers, infections, inflammations, and other diseases and disorders. They are versatile in design, synthesis, modification, and functionalization. This has many advantages in terms...

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Bibliographic Details
Published in:Cancers 2022-10, Vol.14 (21), p.5366
Main Authors: Kanu, Gayathri A, Parambath, Javad B. M, Abu Odeh, Raed O, Mohamed, Ahmed A
Format: Article
Language:English
Subjects:
Cancer
Cancer therapies
Care and treatment
CRISPR
Disease
Drug delivery
Gene silencing
Gene therapy
Gene transfer
Genetic disorders
Genomes
Gold
Health aspects
Kinases
Medical research
Methods
Muscular dystrophy
Nanoparticles
Nanotechnology
Peptides
Precision medicine
Proteins
Review
Reviews
Vectors (Biology)
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Description
Summary:Gold nanoparticles (AuNPs) have gained increasing attention as novel drug-delivery nanostructures for the treatment of cancers, infections, inflammations, and other diseases and disorders. They are versatile in design, synthesis, modification, and functionalization. This has many advantages in terms of gene editing and gene silencing, and their application in genetic illnesses. The development of several techniques such as CRISPR/Cas9, TALEN, and ZFNs has raised hopes for the treatment of genetic abnormalities, although more focused experimentation is still needed. AuNPs, however, have been much more effective in trending research on this subject. In this review, we highlight recently well-developed advancements that are relevant to cutting-edge gene therapies, namely gene editing and gene silencing in diseases caused by a single gene in humans by taking an edge of the unique properties of the AuNPs, which will be an important outlook for future research.
ISSN:2072-6694
2072-6694
DOI:10.3390/cancers14215366