Perinatal Outcome and Its Association with Blood Pressure Levels in Women with Preeclampsia

• Published in: Journal of clinical medicine 2022-10, Vol.11 (21), p.6334
• Main Authors: Willy, Daniela, Schmitz, Ralf, Klockenbusch, Walter, Köster, Helen Ann, Willy, Kevin, Braun, Janina, Möllers, Mareike, Oelmeier, Kathrin
• Format: Article
• Language: English
• Subjects: Birth weight; Blood pressure; Cesarean section; Chi-square test; Childbirth & labor; Clinical medicine; Diabetes; Gestational age; Hypertension; Induced labor; Interest groups; Patients; Preeclampsia; Pregnancy; Vagina
• ISSN: 2077-0383; 2077-0383
• DOI: 10.3390/jcm11216334

Background: Timing and mode of delivery in women with preeclampsia remains challenging, often balancing the risk of severe maternal complications and preterm delivery with its risks for the newborn. It is known that women with very high blood pressure levels in pregnancy have more unfavourable outcomes, but there is little data on neonatal outcome in these cases and the effect of the delivery mode. Methods: We included 158 preeclamptic women in our single-centre retrospective cohort study. Patients were divided into three subgroups depending on blood pressure levels, and delivery mode as well as neonatal outcomes were analysed. Furthermore, the effect of gestational age at delivery was assessed. Results: Maternal blood pressure levels correlated negatively with gestational age at delivery (p = 0.007) and positively with delivery via caesarean section (p = 0.003). Induction of labour was more frequent in women with lower blood pressure levels (p = 0.008) and higher gestational age (p < 0.001). If labour was induced, vaginal delivery was achieved equally often in all gestational ages. Neonatal outcome appears to be more favourable after vaginal delivery compared to planned caesarean section (p < 0.001). Conclusions: Induction of labour should be discussed generously in preeclamptic women, even if blood pressure levels are high and/or gestational age is young, as success rates seem to be adequate and neonatal outcome is more favourable after vaginal delivery. Large prospective trials are needed to better evaluate success rates, risks and complications of induced labour and the effects of delivery mode on neonatal outcome in preeclampsia.